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PPARD

GENERAL INFORMATION

Gene name

 PPARD

Gene description

 Peroxisome proliferator-activated receptor delta

Protein class

 FDA approved drug targets
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB017635
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB017635

GENE INFORMATION

Gene name

 PPARD (HGNC Symbol)

Synonyms

 FAAR, NR1C2, NUC1, NUCII

Description

 Peroxisome proliferator-activated receptor delta (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Chromosome

 6

Cytoband

 p21.31

Chromosome location (bp)

 35342558 - 35428191

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112033 (version 83.38)

Entrez gene

 5467

UniProt

 Q03181 (UniProt - Evidence at protein level)

neXtProt

 NX_Q03181

Antibodypedia

 PPARD antibodies

PROTEIN BROWSER
PPARD-002
PPARD-003
PPARD-201
PPARD-202
PPARD-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPARD-002
ENSP00000310928
ENST00000311565
Q03181 [Direct mapping]
Peroxisome proliferator-activated receptor delta
A0A024RCW6 [Target identity:100%; Query identity:100%]
Peroxisome proliferative activated receptor, delta, isoform CRA_a
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001890 [placenta development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005504 [fatty acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006006 [glucose metabolic process]
GO:0006029 [proteoglycan metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0006776 [vitamin A metabolic process]
GO:0006915 [apoptotic process]
GO:0007507 [heart development]
GO:0007566 [embryo implantation]
GO:0008144 [drug binding]
GO:0008203 [cholesterol metabolic process]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0008366 [axon ensheathment]
GO:0008654 [phospholipid biosynthetic process]
GO:0009062 [fatty acid catabolic process]
GO:0009299 [mRNA transcription]
GO:0009749 [response to glucose]
GO:0010033 [response to organic substance]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014823 [response to activity]
GO:0014842 [regulation of satellite cell proliferation]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0015758 [glucose transport]
GO:0015908 [fatty acid transport]
GO:0019395 [fatty acid oxidation]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031589 [cell-substrate adhesion]
GO:0032024 [positive regulation of insulin secretion]
GO:0032966 [negative regulation of collagen biosynthetic process]
GO:0033189 [response to vitamin A]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell proliferation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043415 [positive regulation of skeletal muscle tissue regeneration]
GO:0043565 [sequence-specific DNA binding]
GO:0043616 [keratinocyte proliferation]
GO:0045598 [regulation of fat cell differentiation]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0045684 [positive regulation of epidermis development]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045909 [positive regulation of vasodilation]
GO:0046697 [decidualization]
GO:0046982 [protein heterodimerization activity]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050728 [negative regulation of inflammatory response]
GO:0051059 [NF-kappaB binding]
GO:0051546 [keratinocyte migration]
GO:0060612 [adipose tissue development]
GO:0070539 [linoleic acid binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071456 [cellular response to hypoxia]
GO:0097190 [apoptotic signaling pathway]
GO:2000288 [positive regulation of myoblast proliferation]
Show all
 441 aa
49.9 kDa 		No 0
PPARD-003
ENSP00000337063
ENST00000337400
Q03181 [Direct mapping]
Peroxisome proliferator-activated receptor delta
F1D8S7 [Target identity:100%; Query identity:100%]
Peroxisome proliferative activated receptor, delta, isoform CRA_b; Peroxisome proliferator-activated nuclear receptor beta/delta variant 2
Show all
Nuclear receptors
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0006915 [apoptotic process]
GO:0007566 [embryo implantation]
GO:0008144 [drug binding]
GO:0008203 [cholesterol metabolic process]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008289 [lipid binding]
GO:0008366 [axon ensheathment]
GO:0009062 [fatty acid catabolic process]
GO:0010467 [gene expression]
GO:0015758 [glucose transport]
GO:0015908 [fatty acid transport]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046697 [decidualization]
GO:0070539 [linoleic acid binding]
GO:0097190 [apoptotic signaling pathway]
Show all
 361 aa
40.4 kDa 		No 0
PPARD-201
ENSP00000353916
ENST00000360694
Q03181 [Direct mapping]
Peroxisome proliferator-activated receptor delta
A0A024RCW6 [Target identity:100%; Query identity:100%]
Peroxisome proliferative activated receptor, delta, isoform CRA_a
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0006915 [apoptotic process]
GO:0007566 [embryo implantation]
GO:0008144 [drug binding]
GO:0008203 [cholesterol metabolic process]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008289 [lipid binding]
GO:0008366 [axon ensheathment]
GO:0009062 [fatty acid catabolic process]
GO:0010467 [gene expression]
GO:0015758 [glucose transport]
GO:0015908 [fatty acid transport]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046697 [decidualization]
GO:0070539 [linoleic acid binding]
GO:0097190 [apoptotic signaling pathway]
Show all
 441 aa
49.9 kDa 		No 0
PPARD-202
ENSP00000413314
ENST00000418635
Q03181 [Direct mapping]
Peroxisome proliferator-activated receptor delta
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0006915 [apoptotic process]
GO:0007566 [embryo implantation]
GO:0008144 [drug binding]
GO:0008203 [cholesterol metabolic process]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008289 [lipid binding]
GO:0008366 [axon ensheathment]
GO:0009062 [fatty acid catabolic process]
GO:0010467 [gene expression]
GO:0015758 [glucose transport]
GO:0015908 [fatty acid transport]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046697 [decidualization]
GO:0070539 [linoleic acid binding]
GO:0097190 [apoptotic signaling pathway]
Show all
 343 aa
38.9 kDa 		No 0
PPARD-203
ENSP00000414372
ENST00000448077
Q03181 [Direct mapping]
Peroxisome proliferator-activated receptor delta
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0006915 [apoptotic process]
GO:0007566 [embryo implantation]
GO:0008144 [drug binding]
GO:0008203 [cholesterol metabolic process]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008289 [lipid binding]
GO:0008366 [axon ensheathment]
GO:0009062 [fatty acid catabolic process]
GO:0010467 [gene expression]
GO:0015758 [glucose transport]
GO:0015908 [fatty acid transport]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046697 [decidualization]
GO:0070539 [linoleic acid binding]
GO:0097190 [apoptotic signaling pathway]
Show all
 402 aa
45.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.