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Antibody staining not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
A single cases each of breast and colorectal cancers exhibited strong cytoplasmic positivity in a fraction of tumor cells. Remaining of the tumors were negative.
GENE INFORMATION
Gene name
IL17A (HGNC Symbol)
Synonyms
CTLA8, IL-17, IL-17A, IL17
Description
Interleukin 17A (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]