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MCM3

GENERAL INFORMATION

Gene name

 MCM3

Gene description

 Minichromosome maintenance complex component 3

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in proliferating cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA004789 , HPA004790 , CAB002162
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable), melanoma (unfavourable), liver cancer (unfavourable) and cervical cancer (favourable).
Thyroid cancer p<0.001
Melanoma p<0.001
Liver cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA004789
HPA004790
CAB002162

GENE INFORMATION

Gene name

 MCM3

Synonyms

Description

 Minichromosome maintenance complex component 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 6

Cytoband

 p12.2

Chromosome location (bp)

 52264009 - 52284881

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112118 (version 83.38)

Entrez gene

 4172

UniProt

 P25205 (UniProt - Evidence at protein level)

neXtProt

 NX_P25205

Antibodypedia

 MCM3 antibodies

PROTEIN BROWSER
MCM3-001
MCM3-004
MCM3-006
MCM3-201
MCM3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MCM3-001
ENSP00000472940
ENST00000596288
P25205 [Direct mapping]
DNA replication licensing factor MCM3
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003678 [DNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005658 [alpha DNA polymerase:primase complex]
GO:0005813 [centrosome]
GO:0006260 [DNA replication]
GO:0006270 [DNA replication initiation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0016020 [membrane]
GO:0032508 [DNA duplex unwinding]
GO:0042555 [MCM complex]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048471 [perinuclear region of cytoplasm]
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 853 aa
95.9 kDa 		No 0
MCM3-004
ENSP00000407651
ENST00000421471
Q7Z6P5 [Direct mapping]
DNA replication licensing factor MCM3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0043231 [intracellular membrane-bounded organelle]
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 328 aa
37.4 kDa 		No 0
MCM3-006
ENSP00000229854
ENST00000229854
P25205 [Direct mapping]
DNA replication licensing factor MCM3
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003678 [DNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005658 [alpha DNA polymerase:primase complex]
GO:0005813 [centrosome]
GO:0006260 [DNA replication]
GO:0006270 [DNA replication initiation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0016020 [membrane]
GO:0032508 [DNA duplex unwinding]
GO:0042555 [MCM complex]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048471 [perinuclear region of cytoplasm]
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 808 aa
91 kDa 		No 0
MCM3-201
ENSP00000388647
ENST00000419835
J3KQ69 [Direct mapping]
DNA replication licensing factor MCM3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003678 [DNA helicase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0006260 [DNA replication]
GO:0006270 [DNA replication initiation]
GO:0032508 [DNA duplex unwinding]
GO:0042555 [MCM complex]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 818 aa
91.9 kDa 		No 0
MCM3-202
ENSP00000480987
ENST00000616552
P25205 [Direct mapping]
DNA replication licensing factor MCM3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003678 [DNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005658 [alpha DNA polymerase:primase complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006260 [DNA replication]
GO:0006270 [DNA replication initiation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0016020 [membrane]
GO:0032508 [DNA duplex unwinding]
GO:0042555 [MCM complex]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 853 aa
95.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.