Expression of MDGA1 in cancer - Summary - The Human Protein Atlas

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MDGA1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MDGA1
Gene description	MAM domain containing glycosylphosphatidylinositol anchor 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues, including CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA031235 , HPA050382
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031235	HPA050382

GENE INFORMATION
Gene name	MDGA1 (HGNC Symbol)
Synonyms	GPIM, MAMDC3
Description	MAM domain containing glycosylphosphatidylinositol anchor 1 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p21.2
Chromosome location (bp)	37630679 - 37699306
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112139 (version 83.38)
Entrez gene	266727
UniProt	Q8NFP4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NFP4
Antibodypedia	MDGA1 antibodies

PROTEIN BROWSER

MDGA1-001	MDGA1-003	MDGA1-007	MDGA1-008	MDGA1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MDGA1-001 ENSP00000402584 ENST00000434837	Q8NFP4 [Direct mapping] MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0001764 [neuron migration] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007420 [brain development] GO:0016020 [membrane] GO:0021527 [spinal cord association neuron differentiation] GO:0021799 [cerebral cortex radially oriented cell migration] GO:0046658 [anchored component of plasma membrane] Show all	955 aa 105.8 kDa	Yes	0
MDGA1-003 ENSP00000422042 ENST00000505425	Q8NFP4 [Direct mapping] MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001764 [neuron migration] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007420 [brain development] GO:0016020 [membrane] GO:0021527 [spinal cord association neuron differentiation] GO:0046658 [anchored component of plasma membrane] Show all	973 aa 107.3 kDa	Yes	0
MDGA1-007 ENSP00000421510 ENST00000515437	D6RFG6 [Direct mapping] MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	129 aa 14.6 kDa	No	0
MDGA1-008 ENSP00000427645 ENST00000508399	D6RHU8 [Direct mapping] MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	77 aa 8.7 kDa	No	0
MDGA1-012 ENSP00000393330 ENST00000418178	H0Y4Q2 [Direct mapping] MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Show all	Predicted intracellular proteins Show all	GO:0016020 [membrane] Show all	160 aa 18.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.