Expression of BAG2 in cancer - Summary - The Human Protein Atlas

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BAG2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BAG2
Gene description	BCL2-associated athanogene 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (smooth muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including smooth muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining in cells/structures not annotated, view images. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA018862 , HPA019918
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and thyroid cancer (unfavourable).
Liver cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Endometrial cancer

STAINING SUMMARY

HPA018862	HPA019918

GENE INFORMATION
Gene name	BAG2
Synonyms
Description	BCL2-associated athanogene 2 (HGNC Symbol)
Entrez gene summary	BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p12.1
Chromosome location (bp)	57172326 - 57189833
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112208 (version 83.38)
Entrez gene	9532
UniProt	O95816 (UniProt - Evidence at protein level)
neXtProt	NX_O95816
Antibodypedia	BAG2 antibodies

PROTEIN BROWSER

BAG2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BAG2-001 ENSP00000359727 ENST00000370693	O95816 [Direct mapping] BAG family molecular chaperone regulator 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006457 [protein folding] GO:0019538 [protein metabolic process] GO:0034605 [cellular response to heat] GO:0042802 [identical protein binding] GO:0051087 [chaperone binding] GO:1900034 [regulation of cellular response to heat] Show all	211 aa 23.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.