Cell atlas - GPR63 - The Human Protein Atlas

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GPR63

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	GPR63
Gene description	G protein-coupled receptor 63
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus, plasma membrane & cytosol.
RNA cell category	Cell line enhanced (Karpas-707, HDLM-2)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleus (uncertain), Plasma membrane (approved), Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA039103
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707, HDLM-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus, plasma membrane & cytosol.

Main location

Nucleus (uncertain), Plasma membrane (approved), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039103	HEK 293	Nucleus
	HPA039103	HEK 293	Cytosol
	HPA039103	U-2 OS	Nucleus
			Plasma membrane
			Cytosol
	HPA039103	U-251 MG	Nucleus
	HPA039103	U-251 MG	Cytosol

GENE INFORMATION
Gene name	GPR63 (HGNC Symbol)
Synonyms	PSP24(beta), PSP24B
Description	G protein-coupled receptor 63 (HGNC Symbol)
Entrez gene summary	This gene encodes a G protein-coupled receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Chromosome	6
Cytoband	q16.1
Chromosome location (bp)	96794126 - 96837463
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000112218 (version 83.38)
Entrez gene	81491
UniProt	Q9BZJ6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BZJ6
Antibodypedia	GPR63 antibodies

PROTEIN BROWSER

GPR63-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPR63-001 ENSP00000229955 ENST00000229955	Q9BZJ6 [Direct mapping] Probable G-protein coupled receptor 63 A8K1C4 [Target identity:100%; Query identity:100%] G protein-coupled receptor 63; cDNA FLJ78200, highly similar to Homo sapiens PSP24; cDNA, FLJ94093, Homo sapiens G protein-coupled receptor 63 (GPR63), mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0043235 [receptor complex] Show all	419 aa 47.6 kDa	Yes	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.