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FBXL4

GENERAL INFORMATION

Gene name

 FBXL4

Gene description

 F-box and leucine-rich repeat protein 4

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA029140 , CAB033362
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA029140
CAB033362

GENE INFORMATION

Gene name

 FBXL4 (HGNC Symbol)

Synonyms

 FBL4, FBL5

Description

 F-box and leucine-rich repeat protein 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 6

Cytoband

Chromosome location (bp)

 98868538 - 98948006

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112234 (version 83.38)

Entrez gene

 26235

UniProt

 Q9UKA2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKA2

Antibodypedia

 FBXL4 antibodies

PROTEIN BROWSER
FBXL4-001
FBXL4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FBXL4-001
ENSP00000358247
ENST00000369244
Q9UKA2 [Direct mapping]
F-box/LRR-repeat protein 4
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   MEMSAT3 predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0000151 [ubiquitin ligase complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005758 [mitochondrial intermembrane space]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
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 621 aa
70.1 kDa 		No 0
FBXL4-201
ENSP00000229971
ENST00000229971
Q9UKA2 [Direct mapping]
F-box/LRR-repeat protein 4
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   MEMSAT3 predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005758 [mitochondrial intermembrane space]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 621 aa
70.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.