Cell atlas - CCNC - The Human Protein Atlas

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CCNC

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CCNC
Gene description	Cyclin C
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. CAB010499 , HPA069322
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (supported)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB010499	A-431	Nucleoplasm
	CAB010499	A-431	Cytosol
	CAB010499	U-2 OS	Nucleoplasm
	CAB010499	U-2 OS	Cytosol
	CAB010499	U-251 MG	Nucleus
	CAB010499	U-251 MG	Cytosol
	HPA069322	RT4	Nucleoplasm
	HPA069322	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	CCNC (HGNC Symbol)
Synonyms	CycC
Description	Cyclin C (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q16.2
Chromosome location (bp)	99542380 - 99568973
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112237 (version 83.38)
Entrez gene	892
UniProt	P24863 (UniProt - Evidence at protein level)
neXtProt	NX_P24863
Antibodypedia	CCNC antibodies

PROTEIN BROWSER

CCNC-001	CCNC-002	CCNC-003	CCNC-004	CCNC-005	CCNC-007	CCNC-008	CCNC-011	CCNC-012	CCNC-013	CCNC-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCNC-001 ENSP00000428982 ENST00000520429	P24863 [Direct mapping] Cyclin-C Q7Z4L3 [Target identity:100%; Query identity:100%] Cyclin C; Cyclin C, isoform CRA_a Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0010467 [gene expression] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016567 [protein ubiquitination] GO:0016592 [mediator complex] GO:0019901 [protein kinase binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0061630 [ubiquitin protein ligase activity] GO:0090209 [negative regulation of triglyceride metabolic process] GO:1901409 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain] Show all	283 aa 33.2 kDa	No	0
CCNC-002 ENSP00000430077 ENST00000486428	H0YBQ5 [Direct mapping] Cyclin-C Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016592 [mediator complex] GO:0019901 [protein kinase binding] Show all	228 aa 26.5 kDa	No	0
CCNC-003 ENSP00000430294 ENST00000518714	E5RFK5 [Direct mapping] Cyclin-C Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016592 [mediator complex] GO:0019901 [protein kinase binding] Show all	282 aa 33.1 kDa	No	0
CCNC-004 ENSP00000428472 ENST00000369217	E5RI39 [Direct mapping] Cyclin-C Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016592 [mediator complex] GO:0019901 [protein kinase binding] Show all	192 aa 22.5 kDa	No	0
CCNC-005 ENSP00000417072 ENST00000482541	Q5JV82 [Direct mapping] Cyclin-C Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016592 [mediator complex] GO:0019901 [protein kinase binding] Show all	143 aa 16.8 kDa	No	0
CCNC-007 ENSP00000430381 ENST00000520371	E5RFK5 [Direct mapping] Cyclin-C Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016592 [mediator complex] GO:0019901 [protein kinase binding] Show all	282 aa 33.1 kDa	No	0
CCNC-008 ENSP00000430119 ENST00000523985	P24863 [Direct mapping] Cyclin-C Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0010467 [gene expression] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0019901 [protein kinase binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:1901409 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain] Show all	198 aa 22.9 kDa	No	0
CCNC-011 ENSP00000358222 ENST00000369220	J3KP90 [Direct mapping] Cyclin-C Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016592 [mediator complex] GO:0019901 [protein kinase binding] Show all	282 aa 33.1 kDa	No	0
CCNC-012 ENSP00000427885 ENST00000524049	E5RFX8 [Direct mapping] Cyclin-C Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016592 [mediator complex] GO:0019901 [protein kinase binding] Show all	162 aa 19.1 kDa	No	0
CCNC-013 ENSP00000430014 ENST00000523799	P24863 [Direct mapping] Cyclin-C Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0010467 [gene expression] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0019901 [protein kinase binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:1901409 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain] Show all	198 aa 22.9 kDa	No	0
CCNC-201 ENSP00000487040 ENST00000627680	G5E954 [Direct mapping] Cyclin C, isoform CRA_c; Cyclin-C Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016592 [mediator complex] GO:0019901 [protein kinase binding] Show all	202 aa 24 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.