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PTP4A1

GENERAL INFORMATION

Gene name

 PTP4A1

Gene description

 Protein tyrosine phosphatase type IVA, member 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 1 antibody.
HPA003281
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003281

GENE INFORMATION

Gene name

 PTP4A1 (HGNC Symbol)

Synonyms

 PRL-1, PTPCAAX1

Description

 Protein tyrosine phosphatase type IVA, member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

Chromosome

 6

Cytoband

 q12

Chromosome location (bp)

 63521761 - 63583587

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112245 (version 83.38)

Entrez gene

 7803

UniProt

 Q93096 (UniProt - Evidence at protein level)

neXtProt

 NX_Q93096

Antibodypedia

 PTP4A1 antibodies

PROTEIN BROWSER
PTP4A1-004
PTP4A1-005
PTP4A1-201
PTP4A1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTP4A1-004
ENSP00000359685
ENST00000370651
Q93096 [Direct mapping]
Protein tyrosine phosphatase type IVA 1
A0A024R8J2 [Target identity:100%; Query identity:100%]
Protein tyrosine phosphatase type IVA, member 1, isoform CRA_a
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005819 [spindle]
GO:0006470 [protein dephosphorylation]
GO:0007049 [cell cycle]
GO:0007275 [multicellular organismal development]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0030335 [positive regulation of cell migration]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0070062 [extracellular exosome]
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 173 aa
19.8 kDa 		No 0
PTP4A1-005
ENSP00000462406
ENST00000578299
J3KSB4 [Direct mapping]
Protein tyrosine phosphatase type IVA 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 44 aa
5 kDa 		No 0
PTP4A1-201
ENSP00000485687
ENST00000626021
Q93096 [Direct mapping]
Protein tyrosine phosphatase type IVA 1
A0A024R8J2 [Target identity:100%; Query identity:100%]
Protein tyrosine phosphatase type IVA, member 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005819 [spindle]
GO:0006470 [protein dephosphorylation]
GO:0007049 [cell cycle]
GO:0007275 [multicellular organismal development]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0030335 [positive regulation of cell migration]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0070062 [extracellular exosome]
Show all
 173 aa
19.8 kDa 		No 0
PTP4A1-202
ENSP00000487586
ENST00000627002
A0A0D9SGK2 [Direct mapping]
Protein tyrosine phosphatase type IVA 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
Show all
 148 aa
17.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.