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SIM1

GENERAL INFORMATION

Gene name

 SIM1

Gene description

 Single-minded family bHLH transcription factor 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (renal cancer)
HPA (cell line):Cell line enhanced (BJ, BJ hTERT+, RPTEC TERT1)
HPA (normal tissue):Tissue enhanced (epididymis, kidney, seminal vesicle)

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SIM1 (HGNC Symbol)

Synonyms

 bHLHe14

Description

 Single-minded family bHLH transcription factor 1 (HGNC Symbol)

Entrez gene summary

 SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q16.3

Chromosome location (bp)

 100385015 - 100464929

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000112246 (version 83.38)

Entrez gene

 6492

UniProt

 P81133 (UniProt - Evidence at transcript level)

neXtProt

 NX_P81133

Antibodypedia

 SIM1 antibodies

PROTEIN BROWSER
SIM1-001
SIM1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SIM1-001
ENSP00000358210
ENST00000369208
P81133 [Direct mapping]
Single-minded homolog 1
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Basic domains
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001657 [ureteric bud development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007399 [nervous system development]
GO:0030154 [cell differentiation]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
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 766 aa
85.5 kDa 		No 0
SIM1-201
ENSP00000262901
ENST00000262901
P81133 [Direct mapping]
Single-minded homolog 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Basic domains
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007399 [nervous system development]
GO:0030154 [cell differentiation]
GO:0046983 [protein dimerization activity]
Show all
 766 aa
85.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.