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ASCC3

GENERAL INFORMATION

Gene name

 ASCC3

Gene description

 Activating signal cointegrator 1 complex subunit 3

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Pending retesting.

Reliability score

 Approved based on 3 antibodies.
HPA031608 , HPA031609 , HPA031610
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA031608
HPA031609
HPA031610

GENE INFORMATION

Gene name

 ASCC3 (HGNC Symbol)

Synonyms

 ASC1p200, dJ121G13.4, dJ467N11.1, HELIC1, RNAH

Description

 Activating signal cointegrator 1 complex subunit 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 6

Cytoband

 q16.3

Chromosome location (bp)

 100508194 - 100881372

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112249 (version 83.38)

Entrez gene

 10973

UniProt

 Q8N3C0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N3C0

Antibodypedia

 ASCC3 antibodies

PROTEIN BROWSER
ASCC3-001
ASCC3-002
ASCC3-004
ASCC3-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASCC3-001
ENSP00000358159
ENST00000369162
Q8N3C0 [Direct mapping]
Activating signal cointegrator 1 complex subunit 3
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006281 [DNA repair]
GO:0006307 [DNA dealkylation involved in DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008283 [cell proliferation]
GO:0008565 [protein transporter activity]
GO:0016020 [membrane]
GO:0031204 [posttranslational protein targeting to membrane, translocation]
GO:0032508 [DNA duplex unwinding]
GO:0043140 [ATP-dependent 3'-5' DNA helicase activity]
GO:0044822 [poly(A) RNA binding]
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 2202 aa
251.5 kDa 		No 0
ASCC3-002
ENSP00000358139
ENST00000369143
Q8N3C0 [Direct mapping]
Activating signal cointegrator 1 complex subunit 3
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006281 [DNA repair]
GO:0006307 [DNA dealkylation involved in DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008283 [cell proliferation]
GO:0008565 [protein transporter activity]
GO:0016020 [membrane]
GO:0031204 [posttranslational protein targeting to membrane, translocation]
GO:0032508 [DNA duplex unwinding]
GO:0043140 [ATP-dependent 3'-5' DNA helicase activity]
GO:0044822 [poly(A) RNA binding]
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 111 aa
13 kDa 		No 0
ASCC3-004
ENSP00000430769
ENST00000522650
Q8N3C0 [Direct mapping]
Activating signal cointegrator 1 complex subunit 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006281 [DNA repair]
GO:0006307 [DNA dealkylation involved in DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008283 [cell proliferation]
GO:0008565 [protein transporter activity]
GO:0016020 [membrane]
GO:0031204 [posttranslational protein targeting to membrane, translocation]
GO:0032508 [DNA duplex unwinding]
GO:0043140 [ATP-dependent 3'-5' DNA helicase activity]
GO:0044822 [poly(A) RNA binding]
Show all
 731 aa
83.7 kDa 		No 0
ASCC3-006
ENSP00000320777
ENST00000324723
E5RFZ0 [Direct mapping]
Activating signal cointegrator 1 complex subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
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 176 aa
19.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.