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GPLD1

GENERAL INFORMATION

Gene name

 GPLD1

Gene description

 Glycosylphosphatidylinositol specific phospholipase D1

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enhanced (Daudi, U-698)
HPA (normal tissue):Tissue enhanced (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA012500 , CAB008625
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA012500
CAB008625

GENE INFORMATION

Gene name

 GPLD1

Synonyms

Description

 Glycosylphosphatidylinositol specific phospholipase D1 (HGNC Symbol)

Entrez gene summary

 Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p22.3

Chromosome location (bp)

 24424565 - 24495205

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112293 (version 83.38)

Entrez gene

 2822

UniProt

 P80108 (UniProt - Evidence at protein level)

neXtProt

 NX_P80108

Antibodypedia

 GPLD1 antibodies

PROTEIN BROWSER
GPLD1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPLD1-001
ENSP00000230036
ENST00000230036
P80108 [Direct mapping]
Phosphatidylinositol-glycan-specific phospholipase D
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001503 [ossification]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002062 [chondrocyte differentiation]
GO:0002430 [complement receptor mediated signaling pathway]
GO:0004621 [glycosylphosphatidylinositol phospholipase D activity]
GO:0004630 [phospholipase D activity]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0006507 [GPI anchor release]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0009749 [response to glucose]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0010897 [negative regulation of triglyceride catabolic process]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010983 [positive regulation of high-density lipoprotein particle clearance]
GO:0017080 [sodium channel regulator activity]
GO:0032869 [cellular response to insulin stimulus]
GO:0035690 [cellular response to drug]
GO:0035701 [hematopoietic stem cell migration]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0043065 [positive regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045919 [positive regulation of cytolysis]
GO:0046470 [phosphatidylcholine metabolic process]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0051047 [positive regulation of secretion]
GO:0070062 [extracellular exosome]
GO:0070633 [transepithelial transport]
GO:0071277 [cellular response to calcium ion]
GO:0071397 [cellular response to cholesterol]
GO:0071401 [cellular response to triglyceride]
GO:0071467 [cellular response to pH]
GO:0097241 [hematopoietic stem cell migration to bone marrow]
GO:1900076 [regulation of cellular response to insulin stimulus]
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 840 aa
92.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.