Tissue expression of VNN2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	VNN2
Gene description	Vanin 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (spleen)
GTEx:	Group enriched (lung, spleen)
FANTOM5:	Tissue enhanced (lung, lymph node, spleen)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (lung, spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, lymph node, spleen)

GENE INFORMATION
Gene name	VNN2 (HGNC Symbol)
Synonyms	FOAP-4, GPI-80
Description	Vanin 2 (HGNC Symbol)
Entrez gene summary	This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Chromosome	6
Cytoband	q23.2
Chromosome location (bp)	132743870 - 132763459
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112303 (version 83.38)
Entrez gene	8875
UniProt	O95498 (UniProt - Evidence at protein level)
neXtProt	NX_O95498
Antibodypedia	VNN2 antibodies

PROTEIN BROWSER

VNN2-001	VNN2-002	VNN2-006	VNN2-011	VNN2-012	VNN2-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VNN2-001 ENSP00000322276 ENST00000326499	O95498 [Direct mapping] Vascular non-inflammatory molecule 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006807 [nitrogen compound metabolic process] GO:0006928 [movement of cell or subcellular component] GO:0015939 [pantothenate metabolic process] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0017159 [pantetheine hydrolase activity] GO:0031225 [anchored component of membrane] Show all	520 aa 58.5 kDa	Yes	1
VNN2-002 ENSP00000436822 ENST00000525270	O95498 [Direct mapping] Vascular non-inflammatory molecule 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006807 [nitrogen compound metabolic process] GO:0006928 [movement of cell or subcellular component] GO:0015939 [pantothenate metabolic process] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0017159 [pantetheine hydrolase activity] GO:0031225 [anchored component of membrane] Show all	467 aa 52.8 kDa	No	1
VNN2-006 ENSP00000436935 ENST00000525289	O95498 [Direct mapping] Vascular non-inflammatory molecule 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006807 [nitrogen compound metabolic process] GO:0006928 [movement of cell or subcellular component] GO:0015939 [pantothenate metabolic process] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] GO:0017159 [pantetheine hydrolase activity] GO:0031225 [anchored component of membrane] Show all	299 aa 33.2 kDa	Yes	1
VNN2-011 ENSP00000431451 ENST00000524919	E9PL76 [Direct mapping] Vascular non-inflammatory molecule 2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006807 [nitrogen compound metabolic process] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] Show all	166 aa 18.5 kDa	Yes	0
VNN2-012 ENSP00000434210 ENST00000530536	E9PRD9 [Direct mapping] Vascular non-inflammatory molecule 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006807 [nitrogen compound metabolic process] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] Show all	102 aa 11.5 kDa	No	0
VNN2-013 ENSP00000431680 ENST00000532012	E9PK31 [Direct mapping] Vascular non-inflammatory molecule 2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006807 [nitrogen compound metabolic process] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] Show all	101 aa 11.2 kDa	Yes	0