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ACOT13

GENERAL INFORMATION

Gene name

 ACOT13

Gene description

 Acyl-CoA thioesterase 13

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA019881
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable).
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019881

GENE INFORMATION

Gene name

 ACOT13 (HGNC Symbol)

Synonyms

 HT012, THEM2

Description

 Acyl-CoA thioesterase 13 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]

Chromosome

 6

Cytoband

 p22.3

Chromosome location (bp)

 24667035 - 24705065

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112304 (version 83.38)

Entrez gene

 55856

UniProt

 Q9NPJ3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPJ3

Antibodypedia

 ACOT13 antibodies

PROTEIN BROWSER
ACOT13-001
ACOT13-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACOT13-001
ENSP00000230048
ENST00000230048
Q9NPJ3 [Direct mapping]
Acyl-coenzyme A thioesterase 13 Acyl-coenzyme A thioesterase 13, N-terminally processed
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047617 [acyl-CoA hydrolase activity]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
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 140 aa
15 kDa 		No 0
ACOT13-201
ENSP00000445552
ENST00000537591
Q9NPJ3 [Direct mapping]
Acyl-coenzyme A thioesterase 13 Acyl-coenzyme A thioesterase 13, N-terminally processed
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047617 [acyl-CoA hydrolase activity]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
Show all
 117 aa
12.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.