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GMNN

GENERAL INFORMATION

Gene name

 GMNN

Gene description

 Geminin, DNA replication inhibitor

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in highly proliferating cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA049977 , CAB011458 , CAB047327
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), ovarian cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA049977
CAB011458
CAB047327

GENE INFORMATION

Gene name

 GMNN (HGNC Symbol)

Synonyms

 Gem

Description

 Geminin, DNA replication inhibitor (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]

Chromosome

 6

Cytoband

 p22.3

Chromosome location (bp)

 24774931 - 24786099

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112312 (version 83.38)

Entrez gene

 51053

UniProt

 O75496 (UniProt - Evidence at protein level)

neXtProt

 NX_O75496

Antibodypedia

 GMNN antibodies

PROTEIN BROWSER
GMNN-001
GMNN-002
GMNN-003
GMNN-004
GMNN-006
GMNN-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GMNN-001
ENSP00000230056
ENST00000230056
O75496 [Direct mapping]
Geminin
A0A024QZY7 [Target identity:100%; Query identity:100%]
Geminin, DNA replication inhibitor, isoform CRA_a
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006275 [regulation of DNA replication]
GO:0006461 [protein complex assembly]
GO:0008156 [negative regulation of DNA replication]
GO:0009887 [organ morphogenesis]
GO:0042826 [histone deacetylase binding]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0070491 [repressing transcription factor binding]
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 209 aa
23.6 kDa 		No 0
GMNN-002
ENSP00000348902
ENST00000356509
O75496 [Direct mapping]
Geminin
A0A024QZY7 [Target identity:100%; Query identity:100%]
Geminin, DNA replication inhibitor, isoform CRA_a
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006275 [regulation of DNA replication]
GO:0008156 [negative regulation of DNA replication]
GO:0042826 [histone deacetylase binding]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 209 aa
23.6 kDa 		No 0
GMNN-003
ENSP00000367293
ENST00000378054
E2QRF9 [Direct mapping]
Geminin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006275 [regulation of DNA replication]
GO:0008156 [negative regulation of DNA replication]
GO:0045786 [negative regulation of cell cycle]
Show all
 179 aa
20.5 kDa 		No 0
GMNN-004
ENSP00000419584
ENST00000476555
C9K0U5 [Direct mapping]
Geminin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006275 [regulation of DNA replication]
GO:0008156 [negative regulation of DNA replication]
GO:0045786 [negative regulation of cell cycle]
Show all
 66 aa
7.3 kDa 		No 0
GMNN-006
ENSP00000367298
ENST00000378059
H7C608 [Direct mapping]
Geminin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006275 [regulation of DNA replication]
GO:0008156 [negative regulation of DNA replication]
GO:0045786 [negative regulation of cell cycle]
Show all
 102 aa
11.4 kDa 		No 0
GMNN-201
ENSP00000477506
ENST00000620958
O75496 [Direct mapping]
Geminin
A0A024QZY7 [Target identity:100%; Query identity:100%]
Geminin, DNA replication inhibitor, isoform CRA_a
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006275 [regulation of DNA replication]
GO:0008156 [negative regulation of DNA replication]
GO:0042826 [histone deacetylase binding]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 209 aa
23.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.