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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

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Validation

Method

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Detectable

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Detectable

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Detectable

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Antibodies

Column

 
 
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NR2E1
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

NR2E1

Gene description

Nuclear receptor subfamily 2, group E, member 1

Protein class

Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus)
FANTOM5:Group enriched (brain, caudate, hippocampus, retina)

Protein evidence

Evidence at protein level

Protein expression

Selective expression in CNS.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data. Sub cellular location is contradicted by external data.

Reliability score

Approved based on 1 antibody.
HPA055642
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Caudate

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, hippocampus, retina)

GENE INFORMATION

Gene name

NR2E1 (HGNC Symbol)

Synonyms

TLL, TLX, XTLL

Description

Nuclear receptor subfamily 2, group E, member 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Chromosome

6

Cytoband

q21

Chromosome location (bp)

108166058 - 108188809

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112333 (version 83.38)

Entrez gene

7101

UniProt

Q9Y466 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y466

Antibodypedia

NR2E1 antibodies

PROTEIN BROWSER

NR2E1-001
NR2E1-002
NR2E1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NR2E1-001
ENSP00000357982
ENST00000368986
Q9Y466 [Direct mapping]
Nuclear receptor subfamily 2 group E member 1
B6ZGT9 [Target identity:100%; Query identity:100%]
Nuclear receptor TLX; Nuclear receptor subfamily 2, group E, member 1, isoform CRA_a; Tailes-related receptor
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007399 [nervous system development]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
385 aa
42.6 kDa
No 0
NR2E1-002
ENSP00000357979
ENST00000368983
Q9Y466 [Direct mapping]
Nuclear receptor subfamily 2 group E member 1
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001662 [behavioral fear response]
GO:0002118 [aggressive behavior]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007399 [nervous system development]
GO:0007420 [brain development]
GO:0007601 [visual perception]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008347 [glial cell migration]
GO:0010467 [gene expression]
GO:0019899 [enzyme binding]
GO:0021542 [dentate gyrus development]
GO:0021764 [amygdala development]
GO:0021772 [olfactory bulb development]
GO:0021819 [layer formation in cerebral cortex]
GO:0021872 [forebrain generation of neurons]
GO:0021895 [cerebral cortex neuron differentiation]
GO:0021960 [anterior commissure morphogenesis]
GO:0021987 [cerebral cortex development]
GO:0030198 [extracellular matrix organization]
GO:0035019 [somatic stem cell population maintenance]
GO:0035176 [social behavior]
GO:0042826 [histone deacetylase binding]
GO:0043010 [camera-type eye development]
GO:0043066 [negative regulation of apoptotic process]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045165 [cell fate commitment]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048712 [negative regulation of astrocyte differentiation]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0051128 [regulation of cellular component organization]
GO:0060041 [retina development in camera-type eye]
GO:0060164 [regulation of timing of neuron differentiation]
GO:0060291 [long-term synaptic potentiation]
GO:0090049 [regulation of cell migration involved in sprouting angiogenesis]
GO:2000178 [negative regulation of neural precursor cell proliferation]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000648 [positive regulation of stem cell proliferation]
Show all
422 aa
46.4 kDa
No 0
NR2E1-003
ENSP00000416908
ENST00000426403
A6PVF6 [Direct mapping]
Nuclear receptor subfamily 2 group E member 1
Show all
Predicted intracellular proteins
Show all
46 aa
5.1 kDa
No 0

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