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HBS1L

GENERAL INFORMATION

Gene name

 HBS1L

Gene description

 HBS1-like translational GTPase

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA029728 , HPA029729
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HBS1L (HGNC Symbol)

Synonyms

 DKFZp434g247, EF-1a, eRF3c, ERFS, HBS1, HSPC276, KIAA1038

Description

 HBS1-like translational GTPase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, May 2009]

Chromosome

 6

Cytoband

 q23.3

Chromosome location (bp)

 134960378 - 135103056

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112339 (version 83.38)

Entrez gene

 10767

UniProt

 Q9Y450 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y450

Antibodypedia

 HBS1L antibodies

PROTEIN BROWSER
«
HBS1L-001
HBS1L-003
HBS1L-004
HBS1L-006
HBS1L-007
HBS1L-009
HBS1L-010
HBS1L-011
HBS1L-012
HBS1L-013
HBS1L-014
HBS1L-015
HBS1L-016
HBS1L-017
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HBS1L-001
ENSP00000356811
ENST00000367837
Q9Y450 [Direct mapping]
HBS1-like protein
D9YZV0 [Target identity:100%; Query identity:100%]
HBS1-like (S. cerevisiae)
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006412 [translation]
GO:0006414 [translational elongation]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0032790 [ribosome disassembly]
GO:0070062 [extracellular exosome]
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 684 aa
75.5 kDa 		No 0
HBS1L-003
ENSP00000323566
ENST00000314674
E9PLR4 [Direct mapping]
HBS1-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 215 aa
24.2 kDa 		No 0
HBS1L-004
ENSP00000356796
ENST00000367822
Q9Y450 [Direct mapping]
HBS1-like protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006412 [translation]
GO:0006414 [translational elongation]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0032790 [ribosome disassembly]
GO:0070062 [extracellular exosome]
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 632 aa
70.1 kDa 		No 0
HBS1L-006
ENSP00000356800
ENST00000367826
Q9Y450 [Direct mapping]
HBS1-like protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006412 [translation]
GO:0006414 [translational elongation]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0032790 [ribosome disassembly]
GO:0070062 [extracellular exosome]
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 642 aa
70.6 kDa 		No 0
HBS1L-007
ENSP00000389826
ENST00000415177
J3QT46 [Direct mapping]
HBS1-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
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 619 aa
68.3 kDa 		No 0
HBS1L-009
ENSP00000434533
ENST00000533274
H0YDX7 [Direct mapping]
HBS1-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
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 554 aa
60.6 kDa 		No 0
HBS1L-010
ENSP00000436256
ENST00000527578
B7Z524 [Direct mapping]
HBS1-like protein; cDNA FLJ52343, highly similar to HBS1-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
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 520 aa
57 kDa 		No 0
HBS1L-011
ENSP00000433030
ENST00000529882
E9PMN1 [Direct mapping]
HBS1-like protein
Show all
   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 168 aa
19.2 kDa 		No 0
HBS1L-012
ENSP00000435608
ENST00000525067
E9PJ90 [Direct mapping]
HBS1-like protein
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0016021 [integral component of membrane]
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 118 aa
13.5 kDa 		No 1
HBS1L-013
ENSP00000434855
ENST00000524715
E9PN23 [Direct mapping]
HBS1-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 141 aa
15.9 kDa 		No 0
HBS1L-014
ENSP00000356794
ENST00000367820
G5E991 [Direct mapping]
HBS1-like (S. cerevisiae), isoform CRA_e; HBS1-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 147 aa
16.7 kDa 		No 0
HBS1L-015
ENSP00000432092
ENST00000527507
E9PS53 [Direct mapping]
HBS1-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 142 aa
15.3 kDa 		No 0
HBS1L-016
ENSP00000436620
ENST00000529641
E9PHZ9 [Direct mapping]
HBS1-like protein
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
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 243 aa
26.1 kDa 		No 0
HBS1L-017
ENSP00000436472
ENST00000529169
H0YES5 [Direct mapping]
HBS1-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 170 aa
18.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.