Expression of ADGRG6 in cancer - Summary - The Human Protein Atlas

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ADGRG6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADGRG6
Gene description	Adhesion G protein-coupled receptor G6
Protein class	G-protein coupled receptors Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HUVEC TERT2, MCF7)
HPA (normal tissue):	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly expressed in endothelial cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA017346
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and lung cancer (unfavourable).
Pancreatic cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017346

GENE INFORMATION
Gene name	ADGRG6 (HGNC Symbol)
Synonyms	FLJ14937, GPR126
Description	Adhesion G protein-coupled receptor G6 (HGNC Symbol)
Entrez gene summary	This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009]
Chromosome	6
Cytoband	q24.2
Chromosome location (bp)	142301854 - 142446266
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112414 (version 83.38)
Entrez gene	57211
UniProt	Q86SQ4 (UniProt - Evidence at protein level)
neXtProt	NX_Q86SQ4
Antibodypedia	ADGRG6 antibodies

PROTEIN BROWSER

ADGRG6-001	ADGRG6-003	ADGRG6-005	ADGRG6-006	ADGRG6-007	ADGRG6-008	ADGRG6-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRG6-001 ENSP00000230173 ENST00000230173	Q86SQ4 [Direct mapping] G-protein coupled receptor 126 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1221 aa 136.7 kDa	Yes	7
ADGRG6-003 ENSP00000356580 ENST00000367608	Q86SQ4 [Direct mapping] G-protein coupled receptor 126 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1222 aa 136.9 kDa	Yes	7
ADGRG6-005 ENSP00000438366 ENST00000435011	F5H054 [Direct mapping] Protein ADGRG6 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		141 aa 15.9 kDa	Yes	0
ADGRG6-006 ENSP00000446287 ENST00000541199	F5H2L1 [Direct mapping] Protein ADGRG6 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		241 aa 26.9 kDa	Yes	0
ADGRG6-007 ENSP00000444123 ENST00000508295	H0YGP2 [Direct mapping] Protein ADGRG6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		135 aa 15.5 kDa	No	0
ADGRG6-008 ENSP00000296932 ENST00000296932	Q86SQ4 [Direct mapping] G-protein coupled receptor 126 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1193 aa 133.7 kDa	Yes	7
ADGRG6-009 ENSP00000356581 ENST00000367609	Q86SQ4 [Direct mapping] G-protein coupled receptor 126 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1250 aa 139.9 kDa	Yes	7

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