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SLC22A2

GENERAL INFORMATION

Gene name

 SLC22A2

Gene description

 Solute carrier family 22 (organic cation transporter), member 2

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (kidney)
GTEx:Tissue enriched (kidney)
FANTOM5:Tissue enriched (kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct membranous and cytoplasmic expression in renal tubules.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA008567 , CAB068236 , CAB068237
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)

GENE INFORMATION

Gene name

 SLC22A2 (HGNC Symbol)

Synonyms

 OCT2

Description

 Solute carrier family 22 (organic cation transporter), member 2 (HGNC Symbol)

Entrez gene summary

 Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q25.3

Chromosome location (bp)

 160171061 - 160277638

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112499 (version 83.38)

Entrez gene

 6582

UniProt

 O15244 (UniProt - Evidence at protein level)

neXtProt

 NX_O15244

Antibodypedia

 SLC22A2 antibodies

PROTEIN BROWSER
SLC22A2-001
SLC22A2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC22A2-001
ENSP00000355920
ENST00000366953
O15244 [Direct mapping]
Solute carrier family 22 member 2
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005329 [dopamine transmembrane transporter activity]
GO:0005496 [steroid binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006812 [cation transport]
GO:0006855 [drug transmembrane transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007589 [body fluid secretion]
GO:0015075 [ion transmembrane transporter activity]
GO:0015101 [organic cation transmembrane transporter activity]
GO:0015220 [choline transmembrane transporter activity]
GO:0015651 [quaternary ammonium group transmembrane transporter activity]
GO:0015695 [organic cation transport]
GO:0015697 [quaternary ammonium group transport]
GO:0015871 [choline transport]
GO:0015872 [dopamine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0022857 [transmembrane transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0051608 [histamine transport]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0072488 [ammonium transmembrane transport]
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 555 aa
62.6 kDa 		No >9
SLC22A2-003
ENSP00000355919
ENST00000366952
Q5T7Q5 [Direct mapping]
Solute carrier family 22 member 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0055085 [transmembrane transport]
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 334 aa
37.9 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.