Fields »
ABOUT
HELP
BLOG
PHF1

GENERAL INFORMATION

Gene name

 PHF1

Gene description

 PHD finger protein 1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA031038
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PHF1 (HGNC Symbol)

Synonyms

 MTF2L2, TDRD19C

Description

 PHD finger protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Chromosome

 6

Cytoband

 p21.32

Chromosome location (bp)

 33410399 - 33416453

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112511 (version 83.38)

Entrez gene

 5252

UniProt

 O43189 (UniProt - Evidence at protein level)

neXtProt

 NX_O43189

Antibodypedia

 PHF1 antibodies

PROTEIN BROWSER
PHF1-001
PHF1-002
PHF1-005
PHF1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PHF1-001
ENSP00000363636
ENST00000374512
O43189 [Direct mapping]
PHD finger protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016568 [chromatin modification]
GO:0035064 [methylated histone binding]
GO:0035098 [ESC/E(Z) complex]
GO:0035861 [site of double-strand break]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0061086 [negative regulation of histone H3-K27 methylation]
GO:0061087 [positive regulation of histone H3-K27 methylation]
Show all
 457 aa
49.6 kDa 		No 0
PHF1-002
ENSP00000363640
ENST00000374516
O43189 [Direct mapping]
PHD finger protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016568 [chromatin modification]
GO:0035064 [methylated histone binding]
GO:0035098 [ESC/E(Z) complex]
GO:0035861 [site of double-strand break]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0061086 [negative regulation of histone H3-K27 methylation]
GO:0061087 [positive regulation of histone H3-K27 methylation]
Show all
 567 aa
62.1 kDa 		No 0
PHF1-005
ENSP00000410494
ENST00000427004
A2AB22 [Direct mapping]
PHD finger protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008270 [zinc ion binding]
GO:0031060 [regulation of histone methylation]
GO:0035064 [methylated histone binding]
Show all
 145 aa
15.9 kDa 		No 0
PHF1-006
ENSP00000392697
ENST00000428274
A2AB23 [Direct mapping]
PHD finger protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008270 [zinc ion binding]
GO:0031060 [regulation of histone methylation]
GO:0035064 [methylated histone binding]
Show all
 227 aa
25.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.