Expression of QKI in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	QKI
Gene description	QKI, KH domain containing, RNA binding
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues, most abundant in glial cells of the CNS and placental trophoblasts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA019123 , CAB022602
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and stomach cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA019123	CAB022602

GENE INFORMATION
Gene name	QKI (HGNC Symbol)
Synonyms	QK3
Description	QKI, KH domain containing, RNA binding (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Chromosome	6
Cytoband	q26
Chromosome location (bp)	163414000 - 163578596
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112531 (version 83.38)
Entrez gene	9444
UniProt	Q96PU8 (UniProt - Evidence at protein level)
neXtProt	NX_Q96PU8
Antibodypedia	QKI antibodies

PROTEIN BROWSER

QKI-001	QKI-002	QKI-003	QKI-004	QKI-006	QKI-007	QKI-012	QKI-013	QKI-014	QKI-016	QKI-017	QKI-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
QKI-001 ENSP00000355094 ENST00000361752	Q96PU8 [Direct mapping] Protein quaking Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001570 [vasculogenesis] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006397 [mRNA processing] GO:0007286 [spermatid development] GO:0008366 [axon ensheathment] GO:0008380 [RNA splicing] GO:0010628 [positive regulation of gene expression] GO:0017124 [SH3 domain binding] GO:0042552 [myelination] GO:0042692 [muscle cell differentiation] GO:0042759 [long-chain fatty acid biosynthetic process] GO:0044822 [poly(A) RNA binding] GO:0051028 [mRNA transport] GO:0061158 [3'-UTR-mediated mRNA destabilization] Show all	341 aa 37.7 kDa	No	0
QKI-002 ENSP00000408775 ENST00000453779	Q96PU8 [Direct mapping] Protein quaking Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0017124 [SH3 domain binding] GO:0044822 [poly(A) RNA binding] GO:0051028 [mRNA transport] Show all	319 aa 35.1 kDa	No	0
QKI-003 ENSP00000275262 ENST00000275262	Q96PU8 [Direct mapping] Protein quaking Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0017124 [SH3 domain binding] GO:0044822 [poly(A) RNA binding] GO:0051028 [mRNA transport] Show all	325 aa 36 kDa	No	0
QKI-004 ENSP00000375973 ENST00000392127	Q96PU8 [Direct mapping] Protein quaking Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0017124 [SH3 domain binding] GO:0044822 [poly(A) RNA binding] GO:0051028 [mRNA transport] Show all	319 aa 35.2 kDa	No	0
QKI-006 ENSP00000354867 ENST00000361195	Q96PU8 [Direct mapping] Protein quaking Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0017124 [SH3 domain binding] GO:0044822 [poly(A) RNA binding] GO:0051028 [mRNA transport] Show all	333 aa 36.9 kDa	No	0
QKI-007 ENSP00000408382 ENST00000424802	Q96PU8 [Direct mapping] Protein quaking Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0017124 [SH3 domain binding] GO:0044822 [poly(A) RNA binding] GO:0051028 [mRNA transport] Show all	317 aa 35.2 kDa	No	0
QKI-012 ENSP00000443690 ENST00000544436	F5H8C8 [Direct mapping] Protein quaking Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	100 aa 11.4 kDa	No	0
QKI-013 ENSP00000443106 ENST00000537124	F5H5U6 [Direct mapping] Protein quaking Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	48 aa 5.5 kDa	No	0
QKI-014 ENSP00000440599 ENST00000544823	F5GYM3 [Direct mapping] Protein quaking Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	170 aa 18.9 kDa	No	0
QKI-016 ENSP00000440991 ENST00000537041	F5GXS8 [Direct mapping] Protein quaking Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	160 aa 18 kDa	No	0
QKI-017 ENSP00000441773 ENST00000537883	H0YG47 [Direct mapping] Protein quaking Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	238 aa 25.8 kDa	No	0
QKI-020 ENSP00000442848 ENST00000544361	H0YGD6 [Direct mapping] Protein quaking Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	185 aa 19.7 kDa	No	0