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A few cases of lymphomas, urothelial and pancreatic cancers exhibited weak to moderate cytoplasmic staining. Remaining cancer tissues were mainly negative.
GENE INFORMATION
Gene name
MDFI (HGNC Symbol)
Synonyms
I-mfa
Description
MyoD family inhibitor (HGNC Symbol)
Entrez gene summary
This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008]