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Cytoplasmic expression in a subset of tissues. Distinct positivity in plasma.
ANTIBODY IHC RELIABILITY
Data reliability description
Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Few cases of breast cancers showed weak cytoplasmic and nuclear staining while colorectal and testis cancers displayed weak membranous positivity. Several cases of prostate cancers exhibited weak cytoplasmic, membranous and nuclear staining. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
SMOC2 (HGNC Symbol)
Synonyms
SMAP2
Description
SPARC related modular calcium binding 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Q9H3U7 [Direct mapping] SPARC-related modular calcium-binding protein 2
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q9H3U7 [Direct mapping] SPARC-related modular calcium-binding protein 2
Show all
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)