Expression of CCND3 in cancer - Summary - The Human Protein Atlas

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CCND3

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCND3
Gene description	Cyclin D3
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. CAB000116
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable).
Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB000116

GENE INFORMATION
Gene name	CCND3
Synonyms
Description	Cyclin D3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	41934933 - 42050357
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112576 (version 83.38)
Entrez gene	896
UniProt	P30281 (UniProt - Evidence at protein level)
neXtProt	NX_P30281
Antibodypedia	CCND3 antibodies

PROTEIN BROWSER

CCND3-001	CCND3-002	CCND3-003	CCND3-005	CCND3-006	CCND3-007	CCND3-011	CCND3-012	CCND3-013	CCND3-014	CCND3-019	CCND3-020	CCND3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCND3-001 ENSP00000362082 ENST00000372991	P30281 [Direct mapping] G1/S-specific cyclin-D3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0001934 [positive regulation of protein phosphorylation] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0042098 [T cell proliferation] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	292 aa 32.5 kDa	No	0
CCND3-002 ENSP00000362078 ENST00000372987	Q5T8J1 [Direct mapping] G1/S-specific cyclin-D3 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0007049 [cell cycle] Show all	242 aa 26.2 kDa	No	0
CCND3-003 ENSP00000397545 ENST00000414200	P30281 [Direct mapping] G1/S-specific cyclin-D3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0001934 [positive regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007049 [cell cycle] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0051301 [cell division] Show all	220 aa 24.2 kDa	No	0
CCND3-005 ENSP00000426212 ENST00000511642	P30281 [Direct mapping] G1/S-specific cyclin-D3 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0001934 [positive regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007049 [cell cycle] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0051301 [cell division] Show all	211 aa 22.9 kDa	No	0
CCND3-006 ENSP00000362079 ENST00000372988	P30281 [Direct mapping] G1/S-specific cyclin-D3 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0001934 [positive regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007049 [cell cycle] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0051301 [cell division] Show all	211 aa 22.9 kDa	No	0
CCND3-007 ENSP00000401595 ENST00000415497	P30281 [Direct mapping] G1/S-specific cyclin-D3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0001934 [positive regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007049 [cell cycle] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0051301 [cell division] Show all	96 aa 9.7 kDa	No	0
CCND3-011 ENSP00000423242 ENST00000508143		Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		10 aa 1.1 kDa	No	0
CCND3-012 ENSP00000425334 ENST00000502771	D6RDL3 [Direct mapping] G1/S-specific cyclin-D3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0007049 [cell cycle] Show all	43 aa 4.9 kDa	No	0
CCND3-013 ENSP00000420991 ENST00000514588	D6RDF8 [Direct mapping] G1/S-specific cyclin-D3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0007049 [cell cycle] Show all	47 aa 5.3 kDa	No	0
CCND3-014 ENSP00000425830 ENST00000505064	D6RIX2 [Direct mapping] G1/S-specific cyclin-D3 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0007049 [cell cycle] Show all	118 aa 13.6 kDa	No	0
CCND3-019 ENSP00000421511 ENST00000512426	H0Y8M4 [Direct mapping] G1/S-specific cyclin-D3 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0007049 [cell cycle] Show all	175 aa 19.2 kDa	No	0
CCND3-020 ENSP00000425986 ENST00000510503	D6RI00 [Direct mapping] G1/S-specific cyclin-D3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0007049 [cell cycle] Show all	195 aa 21.7 kDa	No	0
CCND3-201 ENSP00000484424 ENST00000616010	P30281 [Direct mapping] G1/S-specific cyclin-D3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0001934 [positive regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007049 [cell cycle] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0051301 [cell division] Show all	96 aa 9.7 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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