Expression of MRPL2 in cancer - Summary - The Human Protein Atlas

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MRPL2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MRPL2
Gene description	Mitochondrial ribosomal protein L2
Protein class	Predicted secreted proteins Ribosomal proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA007455
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable).
Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007455

GENE INFORMATION
Gene name	MRPL2 (HGNC Symbol)
Synonyms	CGI-22, MRP-L14, RPML14
Description	Mitochondrial ribosomal protein L2 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	43054029 - 43059806
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112651 (version 83.38)
Entrez gene	51069
UniProt	Q5T653 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T653
Antibodypedia	MRPL2 antibodies

PROTEIN BROWSER

MRPL2-001	MRPL2-002	MRPL2-003	MRPL2-006	MRPL2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL2-001 ENSP00000373404 ENST00000388752	Q5T653 [Direct mapping] 39S ribosomal protein L2, mitochondrial Show all	Ribosomal proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0016740 [transferase activity] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	305 aa 33.3 kDa	Yes	0
MRPL2-002 ENSP00000419710 ENST00000468957	C9JZW2 [Direct mapping] 39S ribosomal protein L2, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] Show all	96 aa 10.3 kDa	Yes	0
MRPL2-003 ENSP00000417101 ENST00000487429	C9J5E0 [Direct mapping] 39S ribosomal protein L2, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		94 aa 10 kDa	Yes	0
MRPL2-006 ENSP00000419753 ENST00000489623	C9JZG7 [Direct mapping] 39S ribosomal protein L2, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] Show all	103 aa 11.1 kDa	Yes	0
MRPL2-007 ENSP00000230413 ENST00000230413	C9IY40 [Direct mapping] 39S ribosomal protein L2, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015934 [large ribosomal subunit] GO:0016740 [transferase activity] Show all	225 aa 24.4 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.