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DUSP22

GENERAL INFORMATION

Gene name

 DUSP22

Gene description

 Dual specificity phosphatase 22

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA031394
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all
0.05.010152025303540FPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031394

Cancer

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 Most cancer tissues displayed weak to moderate cytoplasmic and nuclear positivity. Papillary adenocarcinomas of thyroid and a few cases of liver and ovarian cancers were strong staining. A majority of colorectal cancers were negative.

GENE INFORMATION

Gene name

 DUSP22 (HGNC Symbol)

Synonyms

 JKAP, JSP1, MKPX, VHX

Description

 Dual specificity phosphatase 22 (HGNC Symbol)

Entrez gene summary

Chromosome

 6

Cytoband

 p25.3

Chromosome location (bp)

 291630 - 351355

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112679 (version 83.38)

Entrez gene

 56940

UniProt

 Q9NRW4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRW4

Antibodypedia

 DUSP22 antibodies

PROTEIN BROWSER
DUSP22-001
DUSP22-002
DUSP22-006
DUSP22-007
DUSP22-008
DUSP22-011
DUSP22-012
DUSP22-015
DUSP22-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DUSP22-001
ENSP00000345281
ENST00000344450
Q9NRW4 [Direct mapping]
Dual specificity protein phosphatase 22
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000188 [inactivation of MAPK activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006470 [protein dephosphorylation]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008283 [cell proliferation]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
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 184 aa
20.9 kDa 		No 0
DUSP22-002
ENSP00000397459
ENST00000419235
Q9NRW4 [Direct mapping]
Dual specificity protein phosphatase 22
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000188 [inactivation of MAPK activity]
GO:0002710 [negative regulation of T cell mediated immunity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006470 [protein dephosphorylation]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008283 [cell proliferation]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
GO:0050868 [negative regulation of T cell activation]
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 205 aa
23.3 kDa 		No 0
DUSP22-006
ENSP00000474827
ENST00000605315
S4R3M1 [Direct mapping]
Dual-specificity protein phosphatase 22
Show all
Predicted intracellular proteins
Show all
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
Show all
 102 aa
11.9 kDa 		No 0
DUSP22-007
ENSP00000474000
ENST00000605863
S4R378 [Direct mapping]
Dual-specificity protein phosphatase 22
Show all
Predicted intracellular proteins
Show all
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
Show all
 46 aa
5.2 kDa 		No 0
DUSP22-008
ENSP00000474450
ENST00000603881
S4R3K1 [Direct mapping]
Dual-specificity protein phosphatase 22
Show all
Predicted intracellular proteins
Show all
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
Show all
 19 aa
2 kDa 		No 0
DUSP22-011
ENSP00000474646
ENST00000603453
S4R3M1 [Direct mapping]
Dual-specificity protein phosphatase 22
Show all
Predicted intracellular proteins
Show all
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
Show all
 102 aa
11.9 kDa 		No 0
DUSP22-012
ENSP00000474082
ENST00000603296
S4R3A4 [Direct mapping]
Dual-specificity protein phosphatase 22
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
Show all
 75 aa
8.4 kDa 		No 0
DUSP22-015
ENSP00000474505
ENST00000604971
S4R3M1 [Direct mapping]
Dual-specificity protein phosphatase 22
Show all
Predicted intracellular proteins
Show all
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
Show all
 102 aa
11.9 kDa 		No 0
DUSP22-017
ENSP00000475061
ENST00000605035
S4R378 [Direct mapping]
Dual-specificity protein phosphatase 22
Show all
Predicted intracellular proteins
Show all
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
Show all
 46 aa
5.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.