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Most cancer tissues exhibited moderate to strong cytoplasmic staining. A few cases of lymphomas, gliomas and several testis cancers were negative.
GENE INFORMATION
Gene name
VEGFA (HGNC Symbol)
Synonyms
VEGF, VEGF-A, VPF
Description
Vascular endothelial growth factor A (HGNC Symbol)
Entrez gene summary
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
A0A0A0MSH5 [Direct mapping] Vascular endothelial growth factor A
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MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
A0A0A0MSI7 [Direct mapping] Vascular endothelial growth factor A
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MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
A0A0A0MTB2 [Direct mapping] Vascular endothelial growth factor A
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MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
A0A0A0MSH7 [Direct mapping] Vascular endothelial growth factor A
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MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P15692 [Direct mapping] Vascular endothelial growth factor A
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MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [patterning of blood vessels] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002575 [basophil chemotaxis] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0007596 [blood coagulation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0030141 [secretory granule] GO:0030168 [platelet activation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030823 [regulation of cGMP metabolic process] GO:0030855 [epithelial cell differentiation] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0038191 [neuropilin binding] GO:0040007 [growth] GO:0042056 [chemoattractant activity] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor agonist activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1902966 [positive regulation of protein localization to early endosome] GO:1903572 [positive regulation of protein kinase D signaling]
P15692 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [patterning of blood vessels] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002575 [basophil chemotaxis] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0007596 [blood coagulation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0030141 [secretory granule] GO:0030168 [platelet activation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030823 [regulation of cGMP metabolic process] GO:0030855 [epithelial cell differentiation] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0038191 [neuropilin binding] GO:0040007 [growth] GO:0042056 [chemoattractant activity] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor agonist activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1902966 [positive regulation of protein localization to early endosome] GO:1903572 [positive regulation of protein kinase D signaling]
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [patterning of blood vessels] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002575 [basophil chemotaxis] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0007596 [blood coagulation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0030141 [secretory granule] GO:0030168 [platelet activation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030823 [regulation of cGMP metabolic process] GO:0030855 [epithelial cell differentiation] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0038191 [neuropilin binding] GO:0040007 [growth] GO:0042056 [chemoattractant activity] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor agonist activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1902966 [positive regulation of protein localization to early endosome] GO:1903572 [positive regulation of protein kinase D signaling]
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [patterning of blood vessels] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002575 [basophil chemotaxis] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0007596 [blood coagulation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0030141 [secretory granule] GO:0030168 [platelet activation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030823 [regulation of cGMP metabolic process] GO:0030855 [epithelial cell differentiation] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0038191 [neuropilin binding] GO:0040007 [growth] GO:0042056 [chemoattractant activity] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor agonist activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1902966 [positive regulation of protein localization to early endosome] GO:1903572 [positive regulation of protein kinase D signaling]
P15692 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [patterning of blood vessels] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002575 [basophil chemotaxis] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0007596 [blood coagulation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0030141 [secretory granule] GO:0030168 [platelet activation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030823 [regulation of cGMP metabolic process] GO:0030855 [epithelial cell differentiation] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0038191 [neuropilin binding] GO:0040007 [growth] GO:0042056 [chemoattractant activity] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor agonist activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1902966 [positive regulation of protein localization to early endosome] GO:1903572 [positive regulation of protein kinase D signaling]
P15692 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [patterning of blood vessels] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002575 [basophil chemotaxis] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0007596 [blood coagulation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0030141 [secretory granule] GO:0030168 [platelet activation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030823 [regulation of cGMP metabolic process] GO:0030855 [epithelial cell differentiation] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0038191 [neuropilin binding] GO:0040007 [growth] GO:0042056 [chemoattractant activity] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor agonist activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1902966 [positive regulation of protein localization to early endosome] GO:1903572 [positive regulation of protein kinase D signaling]
P15692 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [patterning of blood vessels] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002575 [basophil chemotaxis] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0007596 [blood coagulation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0030141 [secretory granule] GO:0030168 [platelet activation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030823 [regulation of cGMP metabolic process] GO:0030855 [epithelial cell differentiation] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0038191 [neuropilin binding] GO:0040007 [growth] GO:0042056 [chemoattractant activity] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor agonist activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1902966 [positive regulation of protein localization to early endosome] GO:1903572 [positive regulation of protein kinase D signaling]
P15692 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [patterning of blood vessels] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002575 [basophil chemotaxis] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0007596 [blood coagulation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0030141 [secretory granule] GO:0030168 [platelet activation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030823 [regulation of cGMP metabolic process] GO:0030855 [epithelial cell differentiation] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0038191 [neuropilin binding] GO:0040007 [growth] GO:0042056 [chemoattractant activity] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor agonist activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1902966 [positive regulation of protein localization to early endosome] GO:1903572 [positive regulation of protein kinase D signaling]
J3KPA4 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
A0A087WTP4 [Direct mapping] Vascular endothelial growth factor A
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MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
A0A087X1L1 [Direct mapping] Vascular endothelial growth factor A
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MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
H3BLW8 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)