Cell atlas - WISP3 - The Human Protein Atlas

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WISP3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	WISP3
Gene description	WNT1 inducible signaling pathway protein 3
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Cell line enhanced (RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA062438 , HPA064196
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA062438	U-2 OS	Endoplasmic reticulum
	HPA064196	U-2 OS	Endoplasmic reticulum

GENE INFORMATION
Gene name	WISP3 (HGNC Symbol)
Synonyms	CCN6
Description	WNT1 inducible signaling pathway protein 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q21
Chromosome location (bp)	112054072 - 112070969
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112761 (version 83.38)
Entrez gene	8838
UniProt	O95389 (UniProt - Evidence at protein level)
neXtProt	NX_O95389
Antibodypedia	WISP3 antibodies

PROTEIN BROWSER

WISP3-002	WISP3-007	WISP3-201	WISP3-202	WISP3-203	WISP3-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WISP3-002 ENSP00000357655 ENST00000368666	O95389 [Direct mapping] WNT1-inducible-signaling pathway protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001558 [regulation of cell growth] GO:0005178 [integrin binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0060548 [negative regulation of cell death] Show all	372 aa 41.4 kDa	Yes	0
WISP3-007 ENSP00000473777 ENST00000604763	O95389 [Direct mapping] WNT1-inducible-signaling pathway protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001558 [regulation of cell growth] GO:0005178 [integrin binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0060548 [negative regulation of cell death] Show all	354 aa 39.3 kDa	Yes	0
WISP3-201 ENSP00000230529 ENST00000230529	O95389 [Direct mapping] WNT1-inducible-signaling pathway protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001558 [regulation of cell growth] GO:0005178 [integrin binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0060548 [negative regulation of cell death] Show all	354 aa 39.3 kDa	Yes	0
WISP3-202 ENSP00000354734 ENST00000361714	O95389 [Direct mapping] WNT1-inducible-signaling pathway protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001558 [regulation of cell growth] GO:0005178 [integrin binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0060548 [negative regulation of cell death] Show all	354 aa 39.3 kDa	Yes	0
WISP3-203 ENSP00000357652 ENST00000368663	Q8WYK7 [Direct mapping] WNT1 inducible signaling pathway protein 3 variant; WNT1-inducible-signaling pathway protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001558 [regulation of cell growth] GO:0005178 [integrin binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0008201 [heparin binding] GO:0060548 [negative regulation of cell death] Show all	230 aa 25.1 kDa	Yes	0
WISP3-204 ENSP00000386467 ENST00000409166	Q3T1A9 [Direct mapping] WISP3 protein; WNT1-inducible-signaling pathway protein 3 Show all	Predicted intracellular proteins Show all	GO:0005178 [integrin binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0008201 [heparin binding] GO:0060548 [negative regulation of cell death] Show all	130 aa 14.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.