Expression of LAMA4 in cancer - Summary - The Human Protein Atlas

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LAMA4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LAMA4
Gene description	Laminin, alpha 4
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, HUVEC TERT2, TIME, WM-115)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in smooth muscle cells, basement membranes and decidual cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 2 antibodies. HPA015693 , CAB078156
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015693	CAB078156

GENE INFORMATION
Gene name	LAMA4 (HGNC Symbol)
Synonyms	LAMA3
Description	Laminin, alpha 4 (HGNC Symbol)
Entrez gene summary	Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
Chromosome	6
Cytoband	q21
Chromosome location (bp)	112108760 - 112254939
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112769 (version 83.38)
Entrez gene	3910
UniProt	Q16363 (UniProt - Evidence at protein level)
neXtProt	NX_Q16363
Antibodypedia	LAMA4 antibodies

PROTEIN BROWSER

LAMA4-001	LAMA4-002	LAMA4-003	LAMA4-005	LAMA4-006	LAMA4-007	LAMA4-008	LAMA4-009	LAMA4-010	LAMA4-011	LAMA4-012	LAMA4-014	LAMA4-015	LAMA4-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LAMA4-001 ENSP00000230538 ENST00000230538	A0A0A0MQS9 [Direct mapping] Laminin subunit alpha-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001568 [blood vessel development] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005605 [basal lamina] GO:0007155 [cell adhesion] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0045995 [regulation of embryonic development] GO:0050873 [brown fat cell differentiation] Show all	1823 aa 202.6 kDa	Yes	0
LAMA4-002 ENSP00000412136 ENST00000431543	Q6LET9 [Direct mapping] LAMA4 protein; Laminin subunit alpha-4; Laminin, alpha 4, isoform CRA_a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		129 aa 13.4 kDa	Yes	0
LAMA4-003 ENSP00000357629 ENST00000368640	H0Y351 [Direct mapping] Laminin subunit alpha-4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0045995 [regulation of embryonic development] Show all	178 aa 19.6 kDa	No	0
LAMA4-005 ENSP00000357627 ENST00000368638	Q16363 [Direct mapping] Laminin subunit alpha-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005605 [basal lamina] GO:0007155 [cell adhesion] GO:0030155 [regulation of cell adhesion] GO:0030198 [extracellular matrix organization] GO:0030334 [regulation of cell migration] GO:0031012 [extracellular matrix] GO:0045995 [regulation of embryonic development] GO:0070062 [extracellular exosome] Show all	120 aa 12.8 kDa	Yes	0
LAMA4-006 ENSP00000408604 ENST00000455073	Q16363 [Direct mapping] Laminin subunit alpha-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005605 [basal lamina] GO:0007155 [cell adhesion] GO:0030155 [regulation of cell adhesion] GO:0030198 [extracellular matrix organization] GO:0030334 [regulation of cell migration] GO:0031012 [extracellular matrix] GO:0045995 [regulation of embryonic development] GO:0070062 [extracellular exosome] Show all	120 aa 12.8 kDa	Yes	0
LAMA4-007 ENSP00000427865 ENST00000521732	H0YAQ5 [Direct mapping] Laminin subunit alpha-4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0045995 [regulation of embryonic development] Show all	187 aa 20.5 kDa	No	0
LAMA4-008 ENSP00000429488 ENST00000522006	A0A0A0MTC7 [Direct mapping] Laminin subunit alpha-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0045995 [regulation of embryonic development] Show all	1816 aa 201.8 kDa	Yes	0
LAMA4-009 ENSP00000374114 ENST00000389463	A0A0A0MTC7 [Direct mapping] Laminin subunit alpha-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0045995 [regulation of embryonic development] Show all	1816 aa 201.8 kDa	Yes	0
LAMA4-010 ENSP00000398226 ENST00000453937	Q16363 [Direct mapping] Laminin subunit alpha-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005605 [basal lamina] GO:0007155 [cell adhesion] GO:0030155 [regulation of cell adhesion] GO:0030198 [extracellular matrix organization] GO:0030334 [regulation of cell migration] GO:0031012 [extracellular matrix] GO:0045995 [regulation of embryonic development] GO:0070062 [extracellular exosome] Show all	120 aa 12.8 kDa	Yes	0
LAMA4-011 ENSP00000430336 ENST00000521398	E5RFQ2 [Direct mapping] Laminin subunit alpha-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	331 aa 35.4 kDa	Yes	0
LAMA4-012 ENSP00000416470 ENST00000424408	A0A0A0MTC7 [Direct mapping] Laminin subunit alpha-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0045995 [regulation of embryonic development] Show all	1816 aa 201.8 kDa	Yes	0
LAMA4-014 ENSP00000430415 ENST00000521690	E5RK79 [Direct mapping] Laminin subunit alpha-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		81 aa 8.6 kDa	Yes	0
LAMA4-015 ENSP00000428583 ENST00000519932	E5RHF3 [Direct mapping] Laminin subunit alpha-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		107 aa 11.3 kDa	Yes	0
LAMA4-016 ENSP00000243219 ENST00000243219	E5RFD7 [Direct mapping] Laminin subunit alpha-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		88 aa 9.3 kDa	Yes	0

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