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CLIC5

GENERAL INFORMATION

Gene name

 CLIC5

Gene description

 Chloride intracellular channel 5

Protein class

 Disease related genes
Potential drug targets
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (ovarian cancer)
HPA (cell line):Group enriched (CAPAN-2, EFO-21, HDLM-2, REH, U-266/70)
HPA (normal tissue):Tissue enhanced (lung, skeletal muscle)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (ovarian cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CLIC5 (HGNC Symbol)

Synonyms

 DFNB102

Description

 Chloride intracellular channel 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 45898451 - 46080395

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112782 (version 83.38)

Entrez gene

 53405

UniProt

 Q9NZA1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZA1

Antibodypedia

 CLIC5 antibodies

PROTEIN BROWSER
CLIC5-002
CLIC5-003
CLIC5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLIC5-002
ENSP00000185206
ENST00000185206
Q9NZA1 [Direct mapping]
Chloride intracellular channel protein 5
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002021 [response to dietary excess]
GO:0002024 [diet induced thermogenesis]
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005938 [cell cortex]
GO:0006810 [transport]
GO:0006821 [chloride transport]
GO:0007565 [female pregnancy]
GO:0007605 [sensory perception of sound]
GO:0008104 [protein localization]
GO:0015629 [actin cytoskeleton]
GO:0032420 [stereocilium]
GO:0032421 [stereocilium bundle]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0050885 [neuromuscular process controlling balance]
GO:0060088 [auditory receptor cell stereocilium organization]
GO:0070062 [extracellular exosome]
GO:1902476 [chloride transmembrane transport]
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 410 aa
46.5 kDa 		No 0
CLIC5-003
ENSP00000344165
ENST00000339561
Q9NZA1 [Direct mapping]
Chloride intracellular channel protein 5
Q53G01 [Target identity:100%; Query identity:100%]
Chloride intracellular channel protein
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005938 [cell cortex]
GO:0006810 [transport]
GO:0006821 [chloride transport]
GO:0007565 [female pregnancy]
GO:0007605 [sensory perception of sound]
GO:0015629 [actin cytoskeleton]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0060088 [auditory receptor cell stereocilium organization]
GO:0070062 [extracellular exosome]
GO:1902476 [chloride transmembrane transport]
Show all
 251 aa
28.2 kDa 		No 0
CLIC5-201
ENSP00000439195
ENST00000544153
Q9NZA1 [Direct mapping]
Chloride intracellular channel protein 5
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005938 [cell cortex]
GO:0006810 [transport]
GO:0006821 [chloride transport]
GO:0007565 [female pregnancy]
GO:0007605 [sensory perception of sound]
GO:0015629 [actin cytoskeleton]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0060088 [auditory receptor cell stereocilium organization]
GO:0070062 [extracellular exosome]
GO:1902476 [chloride transmembrane transport]
Show all
 205 aa
22.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.