Expression of ENPP5 in cancer - Summary - The Human Protein Atlas

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ENPP5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ENPP5
Gene description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CAPAN-2, T-47d)
HPA (normal tissue):	Tissue enhanced (epididymis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues including testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA016902
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), pancreatic cancer (favourable) and lung cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016902

GENE INFORMATION
Gene name	ENPP5
Synonyms
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) (HGNC Symbol)
Entrez gene summary	This gene encodes a type-I transmembrane glycoprotein. Studies in rat suggest the encoded protein may play a role in neuronal cell communications. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2014]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	46159187 - 46170971
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112796 (version 83.38)
Entrez gene	59084
UniProt	Q9UJA9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UJA9
Antibodypedia	ENPP5 antibodies

PROTEIN BROWSER

ENPP5-001	ENPP5-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ENPP5-001 ENSP00000360436 ENST00000371383	Q9UJA9 [Direct mapping] Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007154 [cell communication] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] Show all	477 aa 54.7 kDa	Yes	1
ENPP5-002 ENSP00000230565 ENST00000230565	Q9UJA9 [Direct mapping] Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] Show all	477 aa 54.7 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.