Expression of MEP1A in cancer - Summary - The Human Protein Atlas

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MEP1A

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MEP1A
Gene description	Meprin A, alpha (PABA peptide hydrolase)
Protein class	Enzymes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (colorectal cancer)
HPA (cell line):	Cell line enhanced (BEWO, CACO-2, RPMI-8226)
HPA (normal tissue):	Group enriched (colon, duodenum, rectum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in the gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA029416 , CAB025163
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (colorectal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029416	CAB025163

GENE INFORMATION
Gene name	MEP1A (HGNC Symbol)
Synonyms	PPHA
Description	Meprin A, alpha (PABA peptide hydrolase) (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p12.3
Chromosome location (bp)	46793390 - 46839782
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112818 (version 83.38)
Entrez gene	4224
UniProt	Q16819 (UniProt - Evidence at protein level)
neXtProt	NX_Q16819
Antibodypedia	MEP1A antibodies

PROTEIN BROWSER

MEP1A-001	MEP1A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MEP1A-001 ENSP00000230588 ENST00000230588	Q16819 [Direct mapping] Meprin A subunit alpha Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0007586 [digestion] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0017090 [meprin A complex] GO:0070062 [extracellular exosome] Show all	746 aa 84.4 kDa	Yes	1
MEP1A-201 ENSP00000480465 ENST00000611727	B7ZL91 [Direct mapping] Metalloendopeptidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	774 aa 87.9 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.