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TBX18

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GENERAL INFORMATION

Gene name

 TBX18

Gene description

 T-box 18

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (A549, RH-30)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A549, RH-30)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 TBX18

Synonyms

Description

 T-box 18 (HGNC Symbol)

Entrez gene summary

 This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012]

Chromosome

 6

Cytoband

 q14.3

Chromosome location (bp)

 84687351 - 84764519

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112837 (version 83.38)

Entrez gene

 9096

UniProt

 O95935 (UniProt - Evidence at protein level)

neXtProt

 NX_O95935

Antibodypedia

 TBX18 antibodies

PROTEIN BROWSER
TBX18-001
TBX18-002
TBX18-003
TBX18-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TBX18-001
ENSP00000358677
ENST00000369663
O95935 [Direct mapping]
T-box transcription factor TBX18
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0001756 [somitogenesis]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003163 [sinoatrial node development]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007605 [sensory perception of sound]
GO:0009948 [anterior/posterior axis specification]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030154 [cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051145 [smooth muscle cell differentiation]
GO:0060829 [negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation]
GO:0072189 [ureter development]
GO:0090103 [cochlea morphogenesis]
GO:2000729 [positive regulation of mesenchymal cell proliferation involved in ureter development]
Show all
 607 aa
64.8 kDa 		No 0
TBX18-002
ENSP00000476137
ENST00000606621
U3KQQ9 [Direct mapping]
T-box transcription factor TBX18
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 32 aa
3.7 kDa 		No 0
TBX18-003
ENSP00000475498
ENST00000606325
U3KQ31 [Direct mapping]
T-box transcription factor TBX18
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 176 aa
20.2 kDa 		No 0
TBX18-006
ENSP00000475873
ENST00000606784
U3KQH2 [Direct mapping]
T-box transcription factor TBX18
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 232 aa
26.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.