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HARS2

GENERAL INFORMATION

Gene name

 HARS2

Gene description

 Histidyl-tRNA synthetase 2, mitochondrial

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA035941
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), colorectal cancer (favourable) and breast cancer (unfavourable).
Liver cancer p<0.001
Colorectal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA035941

GENE INFORMATION

Gene name

 HARS2 (HGNC Symbol)

Synonyms

 HARSL, HARSR, HO3

Description

 Histidyl-tRNA synthetase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

 Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

 5

Cytoband

 q31.3

Chromosome location (bp)

 140691426 - 140699291

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112855 (version 83.38)

Entrez gene

 23438

UniProt

 P49590 (UniProt - Evidence at protein level)

neXtProt

 NX_P49590

Antibodypedia

 HARS2 antibodies

PROTEIN BROWSER
HARS2-001
HARS2-003
HARS2-004
HARS2-008
HARS2-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HARS2-001
ENSP00000230771
ENST00000230771
P49590 [Direct mapping]
Probable histidine--tRNA ligase, mitochondrial
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Enzymes
   ENZYME proteins
   Ligase
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004821 [histidine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006427 [histidyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0042803 [protein homodimerization activity]
GO:0044822 [poly(A) RNA binding]
Show all
 506 aa
56.9 kDa 		Yes 0
HARS2-003
ENSP00000423616
ENST00000508522
P49590 [Direct mapping]
Probable histidine--tRNA ligase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004821 [histidine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006427 [histidyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0042803 [protein homodimerization activity]
GO:0044822 [poly(A) RNA binding]
Show all
 481 aa
54.1 kDa 		Yes 0
HARS2-004
ENSP00000407105
ENST00000448069
B4DQ67 [Direct mapping]
Probable histidine--tRNA ligase, mitochondrial; cDNA FLJ50611, highly similar to Histidyl-tRNA synthetase homolog (EC 6.1.1.21)
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004821 [histidine-tRNA ligase activity]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006427 [histidyl-tRNA aminoacylation]
Show all
 334 aa
37.2 kDa 		Yes 0
HARS2-008
ENSP00000424516
ENST00000503873
D6RB22 [Direct mapping]
Probable histidine--tRNA ligase, mitochondrial
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004821 [histidine-tRNA ligase activity]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006427 [histidyl-tRNA aminoacylation]
Show all
 116 aa
12.9 kDa 		Yes 0
HARS2-009
ENSP00000425695
ENST00000509299
D6RJE6 [Direct mapping]
Probable histidine--tRNA ligase, mitochondrial
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004821 [histidine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006427 [histidyl-tRNA aminoacylation]
Show all
 181 aa
20.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.