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Most malignant cells showed weak to moderate cytoplasmic immunoreactivity. Malignant melanomas, papillary adenocarcinomas of thyroid along with a few colorectal, endometrial and urothelial cancers were strongly stained.
Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008]