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GHR

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GENERAL INFORMATION

Gene name

 GHR

Gene description

 Growth hormone receptor

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane, cytosol & cytoplasmic bodies.

RNA cell category

 Cell line enriched (T-47d)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported), Cytosol (approved), Cytoplasmic bodies (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA057705
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (T-47d)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane, cytosol & cytoplasmic bodies.

Main location

 Plasma membrane (supported), Cytosol (approved), Cytoplasmic bodies (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA057705 HEK 293 Plasma membrane Intensity
Cytosol
Cytoplasmic bodies
HPA057705 SK-MEL-30 Plasma membrane Intensity
Cytosol
Cytoplasmic bodies
HPA057705 U-2 OS Plasma membrane Intensity
Cytosol
Cytoplasmic bodies

GENE INFORMATION

Gene name

 GHR (HGNC Symbol)

Synonyms

 GHBP

Description

 Growth hormone receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

Chromosome

 5

Cytoband

Chromosome location (bp)

 42423777 - 42721878

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112964 (version 83.38)

Entrez gene

 2690

UniProt

 P10912 (UniProt - Evidence at protein level)

neXtProt

 NX_P10912

Antibodypedia

 GHR antibodies

PROTEIN BROWSER
GHR-001
GHR-201
GHR-202
GHR-203
GHR-204
GHR-205
GHR-206
GHR-207
GHR-208

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GHR-001
ENSP00000230882
ENST00000230882
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
 638 aa
71.5 kDa 		Yes 1
GHR-201
ENSP00000350335
ENST00000357703
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
 616 aa
69.2 kDa 		Yes 1
GHR-202
ENSP00000442206
ENST00000537449
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
 638 aa
71.5 kDa 		Yes 1
GHR-203
ENSP00000478332
ENST00000612382
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
 638 aa
71.5 kDa 		Yes 1
GHR-204
ENSP00000479846
ENST00000612626
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
 638 aa
71.5 kDa 		Yes 1
GHR-205
ENSP00000478291
ENST00000615111
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
 638 aa
71.5 kDa 		Yes 1
GHR-206
ENSP00000482373
ENST00000618088
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
 638 aa
71.5 kDa 		Yes 1
GHR-207
ENSP00000483403
ENST00000620156
A0A087X0H5 [Direct mapping]
Growth hormone receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0004896 [cytokine receptor activity]
GO:0004903 [growth hormone receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0007259 [JAK-STAT cascade]
GO:0009725 [response to hormone]
GO:0009755 [hormone-mediated signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019898 [extrinsic component of membrane]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0032094 [response to food]
GO:0032869 [cellular response to insulin stimulus]
GO:0034097 [response to cytokine]
GO:0042169 [SH2 domain binding]
GO:0042976 [activation of Janus kinase activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043025 [neuronal cell body]
GO:0043278 [response to morphine]
GO:0043434 [response to peptide hormone]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0051384 [response to glucocorticoid]
GO:0060351 [cartilage development involved in endochondral bone morphogenesis]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0070555 [response to interleukin-1]
GO:1901215 [negative regulation of neuron death]
Show all
 645 aa
72.2 kDa 		Yes 1
GHR-208
ENSP00000483926
ENST00000622294
A0A087X162 [Direct mapping]
Growth hormone receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 295 aa
34 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.