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MRPS30

GENERAL INFORMATION

Gene name

 MRPS30

Gene description

 Mitochondrial ribosomal protein S30

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA018686 , HPA021149
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018686
HPA021149

GENE INFORMATION

Gene name

 MRPS30 (HGNC Symbol)

Synonyms

 PAP, PDCD9

Description

 Mitochondrial ribosomal protein S30 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 p12

Chromosome location (bp)

 44808925 - 44820428

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112996 (version 83.38)

Entrez gene

 10884

UniProt

 Q9NP92 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NP92

Antibodypedia

 MRPS30 antibodies

PROTEIN BROWSER
MRPS30-001
MRPS30-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPS30-001
ENSP00000424328
ENST00000507110
Q9NP92 [Direct mapping]
28S ribosomal protein S30, mitochondrial
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Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006915 [apoptotic process]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 439 aa
50.4 kDa 		No 0
MRPS30-201
ENSP00000479189
ENST00000622078
A0A087WV52 [Direct mapping]
28S ribosomal protein S30, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005739 [mitochondrion]
GO:0005840 [ribosome]
GO:0006412 [translation]
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 337 aa
38.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.