Expression of IK in cancer - Summary - The Human Protein Atlas

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IK

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IK
Gene description	IK cytokine, down-regulator of HLA II
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA048798
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and cervical cancer (favourable).
Liver cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048798

GENE INFORMATION
Gene name	IK
Synonyms
Description	IK cytokine, down-regulator of HLA II (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	140647058 - 140662479
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113141 (version 83.38)
Entrez gene	3550
UniProt	Q13123 (UniProt - Evidence at protein level)
neXtProt	NX_Q13123
Antibodypedia	IK antibodies

PROTEIN BROWSER

IK-001	IK-005	IK-006	IK-009	IK-010	IK-201	IK-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IK-001 ENSP00000396301 ENST00000417647	Q13123 [Direct mapping] Protein Red Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006955 [immune response] GO:0007267 [cell-cell signaling] GO:0042802 [identical protein binding] Show all	557 aa 65.6 kDa	No	0
IK-005 ENSP00000425564 ENST00000513256	D6RCQ4 [Direct mapping] Protein Red Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	107 aa 12.6 kDa	No	0
IK-006 ENSP00000426764 ENST00000502899	D6REL4 [Direct mapping] Protein Red Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	212 aa 24.7 kDa	No	0
IK-009 ENSP00000424622 ENST00000507593	D6RAY9 [Direct mapping] Protein Red Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	140 aa 16.4 kDa	No	0
IK-010 ENSP00000422641 ENST00000508301	E7EQZ7 [Direct mapping] Protein Red Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	267 aa 31.2 kDa	No	0
IK-201 ENSP00000481369 ENST00000610522	A0A0C4DGW5 [Direct mapping] Protein Red Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		162 aa 19.4 kDa	No	0
IK-202 ENSP00000480993 ENST00000620556	Q9H4P6 [Direct mapping] Clone TCCCIA00142 mRNA sequence; Protein Red Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	240 aa 28.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.