Expression of PDE8B in cancer - Summary - The Human Protein Atlas

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PDE8B

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PDE8B
Gene description	Phosphodiesterase 8B
Protein class	Disease related genes Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (thyroid cancer)
HPA (cell line):	Cell line enhanced (BJ hTERT+, HeLa)
HPA (normal tissue):	Tissue enriched (thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in thyroid gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA036912
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036912

GENE INFORMATION
Gene name	PDE8B
Synonyms
Description	Phosphodiesterase 8B (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Chromosome	5
Cytoband	q13.3
Chromosome location (bp)	77210449 - 77429807
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113231 (version 83.38)
Entrez gene	8622
UniProt	O95263 (UniProt - Evidence at protein level)
neXtProt	NX_O95263
Antibodypedia	PDE8B antibodies

PROTEIN BROWSER

PDE8B-001	PDE8B-002	PDE8B-003	PDE8B-004	PDE8B-005	PDE8B-006	PDE8B-007	PDE8B-008	PDE8B-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDE8B-001 ENSP00000264917 ENST00000264917	O95263 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000160 [phosphorelay signal transduction system] GO:0001662 [behavioral fear response] GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0008542 [visual learning] GO:0009187 [cyclic nucleotide metabolic process] GO:0035106 [operant conditioning] GO:0046676 [negative regulation of insulin secretion] GO:0046872 [metal ion binding] GO:0050885 [neuromuscular process controlling balance] GO:0090032 [negative regulation of steroid hormone biosynthetic process] Show all	885 aa 99 kDa	No	0
PDE8B-002 ENSP00000345446 ENST00000340978	O95263 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000160 [phosphorelay signal transduction system] GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0009187 [cyclic nucleotide metabolic process] GO:0046872 [metal ion binding] Show all	838 aa 93.7 kDa	No	0
PDE8B-003 ENSP00000330428 ENST00000346042	O95263 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000160 [phosphorelay signal transduction system] GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0009187 [cyclic nucleotide metabolic process] GO:0046872 [metal ion binding] Show all	788 aa 88 kDa	No	0
PDE8B-004 ENSP00000345646 ENST00000342343	O95263 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000160 [phosphorelay signal transduction system] GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0009187 [cyclic nucleotide metabolic process] GO:0046872 [metal ion binding] Show all	865 aa 96.8 kDa	No	0
PDE8B-005 ENSP00000331336 ENST00000333194	O95263 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000160 [phosphorelay signal transduction system] GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0009187 [cyclic nucleotide metabolic process] GO:0046872 [metal ion binding] Show all	830 aa 93 kDa	No	0
PDE8B-006 ENSP00000423461 ENST00000505283	O95263 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0009187 [cyclic nucleotide metabolic process] GO:0046872 [metal ion binding] Show all	350 aa 39.8 kDa	No	0
PDE8B-007 ENSP00000425720 ENST00000505926	D6RJD7 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000160 [phosphorelay signal transduction system] Show all	116 aa 13.2 kDa	No	0
PDE8B-008 ENSP00000426200 ENST00000502945	D6RH10 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000160 [phosphorelay signal transduction system] Show all	112 aa 12.7 kDa	No	0
PDE8B-009 ENSP00000422861 ENST00000503963	D6R9W0 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		119 aa 13.6 kDa	No	0

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