Cell atlas - CLK4 - The Human Protein Atlas

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CLK4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments

Human cell
	Actin Filaments

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GENERAL INFORMATION
Gene name	CLK4
Gene description	CDC-like kinase 4
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the actin filaments.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Actin filaments (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA043746
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the actin filaments.

Main location

Actin filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA043746	A-431	Actin filaments	Intensity
	HPA043746	U-2 OS	Actin filaments	Intensity
	HPA043746	U-251 MG	Actin filaments

GENE INFORMATION
Gene name	CLK4
Synonyms
Description	CDC-like kinase 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	178602664 - 178630615
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113240 (version 83.38)
Entrez gene	57396
UniProt	Q9HAZ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HAZ1
Antibodypedia	CLK4 antibodies

PROTEIN BROWSER

CLK4-001	CLK4-012	CLK4-201	CLK4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLK4-001 ENSP00000316948 ENST00000316308	Q9HAZ1 [Direct mapping] Dual specificity protein kinase CLK4 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0043484 [regulation of RNA splicing] GO:0046777 [protein autophosphorylation] Show all	481 aa 57.5 kDa	No	1
CLK4-012 ENSP00000430892 ENST00000520957	Q6P090 [Direct mapping] CLK4 protein; Dual-specificity protein kinase CLK4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		54 aa 6.7 kDa	No	0
CLK4-201 ENSP00000479788 ENST00000611575	B7ZL31 [Direct mapping] CLK4 protein; Dual-specificity protein kinase CLK4 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	373 aa 44.8 kDa	No	0
CLK4-202 ENSP00000480792 ENST00000611733	A0A087WX74 [Direct mapping] Dual-specificity protein kinase CLK4 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	373 aa 44.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.