Expression of HAVCR1 in cancer - Summary - The Human Protein Atlas

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HAVCR1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	HAVCR1
Gene description	Hepatitis A virus cellular receptor 1
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (renal cancer)
HPA (cell line):	Group enriched (A549, CACO-2, RPTEC TERT1)
HPA (normal tissue):	Group enriched (colon, kidney, rectum, testis)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable) and stomach cancer (unfavourable).
Urothelial cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (renal cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	HAVCR1 (HGNC Symbol)
Synonyms	CD365, HAVCR, HAVCR-1, TIM-1, TIM1, TIMD1
Description	Hepatitis A virus cellular receptor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 12 and 19. [provided by RefSeq, Apr 2015]
Chromosome	5
Cytoband	q33.3
Chromosome location (bp)	157029413 - 157059119
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113249 (version 83.38)
Entrez gene	26762
UniProt	Q96D42 (UniProt - Evidence at protein level)
neXtProt	NX_Q96D42
Antibodypedia	HAVCR1 antibodies

PROTEIN BROWSER

HAVCR1-001	HAVCR1-002	HAVCR1-003	HAVCR1-004	HAVCR1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HAVCR1-001 ENSP00000427898 ENST00000523175	Q96D42 [Direct mapping] Hepatitis A virus cellular receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0031514 [motile cilium] GO:0046718 [viral entry into host cell] Show all	364 aa 39.2 kDa	Yes	1
HAVCR1-002 ENSP00000428524 ENST00000522693	E9PFX0 [Direct mapping] Hepatitis A virus cellular receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	401 aa 44 kDa	Yes	1
HAVCR1-003 ENSP00000344844 ENST00000339252	Q96D42 [Direct mapping] Hepatitis A virus cellular receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0031514 [motile cilium] GO:0046718 [viral entry into host cell] Show all	364 aa 39.2 kDa	Yes	1
HAVCR1-004 ENSP00000428422 ENST00000518745	E5RIF6 [Direct mapping] Hepatitis A virus cellular receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	223 aa 23.9 kDa	Yes	0
HAVCR1-201 ENSP00000487363 ENST00000625904	E9PFX0 [Direct mapping] Hepatitis A virus cellular receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	401 aa 44 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.