Expression of CCNG1 in cancer - Summary - The Human Protein Atlas

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CCNG1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCNG1
Gene description	Cyclin G1
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB000350
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB000350

GENE INFORMATION
Gene name	CCNG1 (HGNC Symbol)
Synonyms	CCNG
Description	Cyclin G1 (HGNC Symbol)
Entrez gene summary	The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q34
Chromosome location (bp)	163437569 - 163446151
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113328 (version 83.38)
Entrez gene	900
UniProt	P51959 (UniProt - Evidence at protein level)
neXtProt	NX_P51959
Antibodypedia	CCNG1 antibodies

PROTEIN BROWSER

CCNG1-001	CCNG1-002	CCNG1-008	CCNG1-009	CCNG1-010	CCNG1-012	CCNG1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCNG1-001 ENSP00000344635 ENST00000340828	P51959 [Direct mapping] Cyclin-G1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007067 [mitotic nuclear division] GO:0051301 [cell division] Show all	295 aa 34.1 kDa	No	0
CCNG1-002 ENSP00000424315 ENST00000512163	P51959 [Direct mapping] Cyclin-G1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007067 [mitotic nuclear division] GO:0051301 [cell division] Show all	161 aa 18.8 kDa	No	0
CCNG1-008 ENSP00000423791 ENST00000510097	D6RCC5 [Direct mapping] Cyclin-G1 Show all	Predicted intracellular proteins Show all	GO:0051726 [regulation of cell cycle] Show all	136 aa 15.6 kDa	No	0
CCNG1-009 ENSP00000421132 ENST00000511490	D6RGX3 [Direct mapping] Cyclin-G1 Show all	Predicted intracellular proteins Show all	GO:0051726 [regulation of cell cycle] Show all	115 aa 13.1 kDa	No	0
CCNG1-010 ENSP00000422379 ENST00000510664	E7ERZ1 [Direct mapping] Cyclin-G1 Show all	Predicted intracellular proteins Show all	GO:0051726 [regulation of cell cycle] Show all	167 aa 19.4 kDa	No	0
CCNG1-012 ENSP00000427086 ENST00000504553	D6RD30 [Direct mapping] Cyclin-G1 Show all	Predicted intracellular proteins Show all	GO:0051726 [regulation of cell cycle] Show all	107 aa 12.5 kDa	No	0
CCNG1-201 ENSP00000377506 ENST00000393929	P51959 [Direct mapping] Cyclin-G1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007067 [mitotic nuclear division] GO:0051301 [cell division] Show all	295 aa 34.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.