Cell atlas - POLR3G - The Human Protein Atlas

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POLR3G

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	POLR3G
Gene description	Polymerase (RNA) III (DNA directed) polypeptide G (32kD)
Protein class	Predicted intracellular proteins RNA polymerase related proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. CAB010109 , HPA052658
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB010109	A-431	Nucleoplasm
	CAB010109	U-2 OS	Nucleoplasm
	CAB010109	U-251 MG	Nucleoplasm
	HPA052658	PC-3	Nucleoplasm
	HPA052658	PC-3	Cytosol
	HPA052658	U-2 OS	Nucleoplasm

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000035834 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA052658	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	POLR3G (HGNC Symbol)
Synonyms	RPC32, RPC7
Description	Polymerase (RNA) III (DNA directed) polypeptide G (32kD) (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q14.3
Chromosome location (bp)	90471748 - 90514553
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113356 (version 83.38)
Entrez gene	10622
UniProt	O15318 (UniProt - Evidence at protein level)
neXtProt	NX_O15318
Antibodypedia	POLR3G antibodies

PROTEIN BROWSER

POLR3G-001	POLR3G-003	POLR3G-004	POLR3G-005	POLR3G-006	POLR3G-007	POLR3G-201	POLR3G-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POLR3G-001 ENSP00000421637 ENST00000504930	O15318 [Direct mapping] DNA-directed RNA polymerase III subunit RPC7 A0A024RAM1 [Target identity:100%; Query identity:100%] Polymerase (RNA) III (DNA directed) polypeptide G (32kD), isoform CRA_a Show all	Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0001056 [RNA polymerase III activity] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005654 [nucleoplasm] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005829 [cytosol] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006383 [transcription from RNA polymerase III promoter] GO:0006384 [transcription initiation from RNA polymerase III promoter] GO:0006385 [transcription elongation from RNA polymerase III promoter] GO:0006386 [termination of RNA polymerase III transcription] GO:0008283 [cell proliferation] GO:0010467 [gene expression] GO:0032481 [positive regulation of type I interferon production] GO:0032728 [positive regulation of interferon-beta production] GO:0045087 [innate immune response] GO:0045089 [positive regulation of innate immune response] GO:0051607 [defense response to virus] Show all	223 aa 25.9 kDa	No	0
POLR3G-003 ENSP00000422164 ENST00000503973	D6R921 [Direct mapping] DNA-directed RNA polymerase III subunit RPC7 Show all	Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001056 [RNA polymerase III activity] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006384 [transcription initiation from RNA polymerase III promoter] Show all	127 aa 15 kDa	No	0
POLR3G-004 ENSP00000427412 ENST00000505345	D6RIT0 [Direct mapping] DNA-directed RNA polymerase III subunit RPC7 Show all	Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001056 [RNA polymerase III activity] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006384 [transcription initiation from RNA polymerase III promoter] Show all	92 aa 10.7 kDa	No	0
POLR3G-005 ENSP00000422892 ENST00000503373	D6R9U7 [Direct mapping] DNA-directed RNA polymerase III subunit RPC7 Show all	Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001056 [RNA polymerase III activity] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006384 [transcription initiation from RNA polymerase III promoter] Show all	221 aa 25.7 kDa	No	0
POLR3G-006 ENSP00000424970 ENST00000512239	D6REQ0 [Direct mapping] DNA-directed RNA polymerase III subunit RPC7 Show all	Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001056 [RNA polymerase III activity] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006384 [transcription initiation from RNA polymerase III promoter] Show all	39 aa 4.2 kDa	No	0
POLR3G-007 ENSP00000425617 ENST00000514483	D6RJH6 [Direct mapping] DNA-directed RNA polymerase III subunit RPC7 Show all	Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001056 [RNA polymerase III activity] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006384 [transcription initiation from RNA polymerase III promoter] Show all	100 aa 11.4 kDa	No	0
POLR3G-201 ENSP00000382058 ENST00000399107	O15318 [Direct mapping] DNA-directed RNA polymerase III subunit RPC7 A0A024RAM1 [Target identity:100%; Query identity:100%] Polymerase (RNA) III (DNA directed) polypeptide G (32kD), isoform CRA_a Show all	Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0001056 [RNA polymerase III activity] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005654 [nucleoplasm] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005829 [cytosol] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006383 [transcription from RNA polymerase III promoter] GO:0006384 [transcription initiation from RNA polymerase III promoter] GO:0006385 [transcription elongation from RNA polymerase III promoter] GO:0006386 [termination of RNA polymerase III transcription] GO:0008283 [cell proliferation] GO:0010467 [gene expression] GO:0032481 [positive regulation of type I interferon production] GO:0032728 [positive regulation of interferon-beta production] GO:0045087 [innate immune response] GO:0045089 [positive regulation of innate immune response] GO:0051607 [defense response to virus] Show all	223 aa 25.9 kDa	No	0
POLR3G-202 ENSP00000478166 ENST00000622335	A0A087WTV7 [Direct mapping] DNA-directed RNA polymerase III subunit RPC7 Show all	Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001056 [RNA polymerase III activity] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006384 [transcription initiation from RNA polymerase III promoter] Show all	233 aa 27.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.