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LMNB1

GENERAL INFORMATION

Gene name

 LMNB1

Gene description

 Lamin B1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (lymph node)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear membrane expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA050524 , HPA053579 , CAB005269
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050524
HPA053579
CAB005269

GENE INFORMATION

Gene name

 LMNB1

Synonyms

Description

 Lamin B1 (HGNC Symbol)

Entrez gene summary

 The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]

Chromosome

 5

Cytoband

 q23.2

Chromosome location (bp)

 126776623 - 126837020

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113368 (version 83.38)

Entrez gene

 4001

UniProt

 P20700 (UniProt - Evidence at protein level)

neXtProt

 NX_P20700

Antibodypedia

 LMNB1 antibodies

PROTEIN BROWSER
LMNB1-001
LMNB1-003
LMNB1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LMNB1-001
ENSP00000261366
ENST00000261366
P20700 [Direct mapping]
Lamin-B1
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005637 [nuclear inner membrane]
GO:0005638 [lamin filament]
GO:0005654 [nucleoplasm]
GO:0005882 [intermediate filament]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016363 [nuclear matrix]
GO:0031965 [nuclear membrane]
GO:0043274 [phospholipase binding]
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 586 aa
66.4 kDa 		No 0
LMNB1-003
ENSP00000378761
ENST00000395354
E9PBF6 [Direct mapping]
Lamin-B1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005637 [nuclear inner membrane]
GO:0005638 [lamin filament]
GO:0005882 [intermediate filament]
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 387 aa
44.6 kDa 		No 0
LMNB1-005
ENSP00000486992
ENST00000492190
A0A0D9SFY5 [Direct mapping]
Lamin-B1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005637 [nuclear inner membrane]
GO:0005638 [lamin filament]
GO:0005882 [intermediate filament]
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 166 aa
18.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.