Expression of NPR3 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

NPR3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NPR3
Gene description	Natriuretic peptide receptor 3
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (renal cancer)
HPA (cell line):	Cell line enhanced (ASC TERT1, HeLa, U-138 MG)
HPA (normal tissue):	Tissue enriched (kidney)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending reevaluation. Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA031065
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031065

GENE INFORMATION
Gene name	NPR3 (HGNC Symbol)
Synonyms	ANPRC, C5orf23, FLJ14054, GUCY2B, NPRC
Description	Natriuretic peptide receptor 3 (HGNC Symbol)
Entrez gene summary	This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Chromosome	5
Cytoband	p13.3
Chromosome location (bp)	32689070 - 32791724
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113389 (version 83.38)
Entrez gene	4883
UniProt	P17342 (UniProt - Evidence at protein level)
neXtProt	NX_P17342
Antibodypedia	NPR3 antibodies

PROTEIN BROWSER

NPR3-001	NPR3-002	NPR3-004	NPR3-005	NPR3-006	NPR3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPR3-001 ENSP00000265074 ENST00000265074	P17342 [Direct mapping] Atrial natriuretic peptide receptor 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0002158 [osteoclast proliferation] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006171 [cAMP biosynthetic process] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0008217 [regulation of blood pressure] GO:0008528 [G-protein coupled peptide receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016941 [natriuretic peptide receptor activity] GO:0017046 [peptide hormone binding] GO:0019933 [cAMP-mediated signaling] GO:0030157 [pancreatic juice secretion] GO:0033688 [regulation of osteoblast proliferation] GO:0035810 [positive regulation of urine volume] GO:0042562 [hormone binding] GO:0042803 [protein homodimerization activity] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0070062 [extracellular exosome] Show all	541 aa 59.8 kDa	Yes	1
NPR3-002 ENSP00000388408 ENST00000434067	C9JK69 [Direct mapping] Atrial natriuretic peptide receptor 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	325 aa 36.7 kDa	No	1
NPR3-004 ENSP00000425325 ENST00000509104	D6RDL8 [Direct mapping] Atrial natriuretic peptide receptor 3 Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	252 aa 28.2 kDa	No	0
NPR3-005 ENSP00000423730 ENST00000507141	H0Y9B9 [Direct mapping] Atrial natriuretic peptide receptor 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		88 aa 10.2 kDa	No	0
NPR3-006 ENSP00000398028 ENST00000415167	P17342 [Direct mapping] Atrial natriuretic peptide receptor 3 Q60I31 [Target identity:100%; Query identity:100%] Natriuretic peptide receptor C; Natriuretic peptide receptor C/guanylate cyclase C (Atrionatriuretic peptide receptor C), isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0002158 [osteoclast proliferation] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006171 [cAMP biosynthetic process] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0008217 [regulation of blood pressure] GO:0008528 [G-protein coupled peptide receptor activity] GO:0016021 [integral component of membrane] GO:0016941 [natriuretic peptide receptor activity] GO:0017046 [peptide hormone binding] GO:0019933 [cAMP-mediated signaling] GO:0033688 [regulation of osteoblast proliferation] GO:0035810 [positive regulation of urine volume] GO:0042562 [hormone binding] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0070062 [extracellular exosome] Show all	540 aa 59.8 kDa	Yes	1
NPR3-201 ENSP00000318340 ENST00000326958	P17342 [Direct mapping] Atrial natriuretic peptide receptor 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0002158 [osteoclast proliferation] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006171 [cAMP biosynthetic process] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0008217 [regulation of blood pressure] GO:0008528 [G-protein coupled peptide receptor activity] GO:0016941 [natriuretic peptide receptor activity] GO:0017046 [peptide hormone binding] GO:0019933 [cAMP-mediated signaling] GO:0033688 [regulation of osteoblast proliferation] GO:0035810 [positive regulation of urine volume] GO:0042562 [hormone binding] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0070062 [extracellular exosome] Show all	324 aa 36.7 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.