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LNPEP

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GENERAL INFORMATION

Gene name

 LNPEP

Gene description

 Leucyl/cystinyl aminopeptidase

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 LNPEP (HGNC Symbol)

Synonyms

 CAP, P-LAP, PLAP

Description

 Leucyl/cystinyl aminopeptidase (HGNC Symbol)

Entrez gene summary

 This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q15

Chromosome location (bp)

 96935394 - 97037515

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113441 (version 83.38)

Entrez gene

 4012

UniProt

 Q9UIQ6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UIQ6

Antibodypedia

 LNPEP antibodies

PROTEIN BROWSER
LNPEP-001
LNPEP-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LNPEP-001
ENSP00000231368
ENST00000231368
Q9UIQ6 [Direct mapping]
Leucyl-cystinyl aminopeptidase Leucyl-cystinyl aminopeptidase, pregnancy serum form
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent]
GO:0004177 [aminopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007565 [female pregnancy]
GO:0008217 [regulation of blood pressure]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0030163 [protein catabolic process]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031905 [early endosome lumen]
GO:0042277 [peptide binding]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0043171 [peptide catabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0060395 [SMAD protein signal transduction]
GO:0061024 [membrane organization]
GO:0070006 [metalloaminopeptidase activity]
Show all
 1025 aa
117.3 kDa 		No 1
LNPEP-002
ENSP00000379117
ENST00000395770
Q9UIQ6 [Direct mapping]
Leucyl-cystinyl aminopeptidase Leucyl-cystinyl aminopeptidase, pregnancy serum form
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent]
GO:0004177 [aminopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007565 [female pregnancy]
GO:0008217 [regulation of blood pressure]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031905 [early endosome lumen]
GO:0042277 [peptide binding]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0043171 [peptide catabolic process]
GO:0061024 [membrane organization]
GO:0070006 [metalloaminopeptidase activity]
Show all
 1011 aa
115.6 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.