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RAD1

GENERAL INFORMATION

Gene name

 RAD1

Gene description

 RAD1 checkpoint DNA exonuclease

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA006692
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and breast cancer (unfavourable).
Liver cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA006692

GENE INFORMATION

Gene name

 RAD1 (HGNC Symbol)

Synonyms

 HRAD1, REC1

Description

 RAD1 checkpoint DNA exonuclease (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]

Chromosome

 5

Cytoband

 p13.2

Chromosome location (bp)

 34905264 - 34918989

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113456 (version 83.38)

Entrez gene

 5810

UniProt

 O60671 (UniProt - Evidence at protein level)

neXtProt

 NX_O60671

Antibodypedia

 RAD1 antibodies

PROTEIN BROWSER
RAD1-001
RAD1-003
RAD1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAD1-001
ENSP00000371469
ENST00000382038
O60671 [Direct mapping]
Cell cycle checkpoint protein RAD1
A0A024R045 [Target identity:100%; Query identity:100%]
HCG37731, isoform CRA_c
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008408 [3'-5' exonuclease activity]
GO:0008853 [exodeoxyribonuclease III activity]
GO:0021762 [substantia nigra development]
GO:0030896 [checkpoint clamp complex]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051598 [meiotic recombination checkpoint]
GO:0071479 [cellular response to ionizing radiation]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 282 aa
31.8 kDa 		No 0
RAD1-003
ENSP00000340879
ENST00000341754
O60671 [Direct mapping]
Cell cycle checkpoint protein RAD1
A0A024R045 [Target identity:100%; Query identity:100%]
HCG37731, isoform CRA_c
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008408 [3'-5' exonuclease activity]
GO:0008853 [exodeoxyribonuclease III activity]
GO:0021762 [substantia nigra development]
GO:0030896 [checkpoint clamp complex]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051598 [meiotic recombination checkpoint]
GO:0071479 [cellular response to ionizing radiation]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 282 aa
31.8 kDa 		No 0
RAD1-201
ENSP00000487478
ENST00000628399
D6R9A1 [Direct mapping]
Cell cycle checkpoint protein RAD1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006281 [DNA repair]
GO:0030896 [checkpoint clamp complex]
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 84 aa
9.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.