Expression of BRIX1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

BRIX1

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BRIX1
Gene description	BRX1, biogenesis of ribosomes
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly nucleolar expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA039614
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), endometrial cancer (unfavourable), breast cancer (unfavourable) and ovarian cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Endometrial cancer p<0.001 Breast cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039614

GENE INFORMATION
Gene name	BRIX1 (HGNC Symbol)
Synonyms	BRIX, BXDC2, FLJ11100
Description	BRX1, biogenesis of ribosomes (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	p13.2
Chromosome location (bp)	34915376 - 34925996
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113460 (version 83.38)
Entrez gene	55299
UniProt	Q8TDN6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDN6
Antibodypedia	BRIX1 antibodies

PROTEIN BROWSER

BRIX1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BRIX1-001 ENSP00000338862 ENST00000336767	Q8TDN6 [Direct mapping] Ribosome biogenesis protein BRX1 homolog Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000027 [ribosomal large subunit assembly] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0044822 [poly(A) RNA binding] Show all	353 aa 41.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.