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AGXT2

GENERAL INFORMATION

Gene name

 AGXT2

Gene description

 Alanine--glyoxylate aminotransferase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (liver cancer, renal cancer)
HPA (cell line):Not detected
HPA (normal tissue):Group enriched (kidney, liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in kidney and liver.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA037382
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (liver cancer, renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037382

GENE INFORMATION

Gene name

 AGXT2 (HGNC Symbol)

Synonyms

 AGT2

Description

 Alanine--glyoxylate aminotransferase 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in this gene affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Chromosome

 5

Cytoband

 p13.2

Chromosome location (bp)

 34998101 - 35048135

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113492 (version 83.38)

Entrez gene

 64902

UniProt

 Q9BYV1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BYV1

Antibodypedia

 AGXT2 antibodies

PROTEIN BROWSER
AGXT2-001
AGXT2-004
AGXT2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AGXT2-001
ENSP00000231420
ENST00000231420
Q9BYV1 [Direct mapping]
Alanine--glyoxylate aminotransferase 2, mitochondrial
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0008453 [alanine-glyoxylate transaminase activity]
GO:0008483 [transaminase activity]
GO:0009436 [glyoxylate catabolic process]
GO:0016223 [beta-alanine-pyruvate transaminase activity]
GO:0019265 [glycine biosynthetic process, by transamination of glyoxylate]
GO:0019481 [L-alanine catabolic process, by transamination]
GO:0030170 [pyridoxal phosphate binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0046135 [pyrimidine nucleoside catabolic process]
GO:0046487 [glyoxylate metabolic process]
GO:0047305 [(R)-3-amino-2-methylpropionate-pyruvate transaminase activity]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 514 aa
57.2 kDa 		No 0
AGXT2-004
ENSP00000422799
ENST00000510428
Q9BYV1 [Direct mapping]
Alanine--glyoxylate aminotransferase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Show all
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0008453 [alanine-glyoxylate transaminase activity]
GO:0008483 [transaminase activity]
GO:0009436 [glyoxylate catabolic process]
GO:0019265 [glycine biosynthetic process, by transamination of glyoxylate]
GO:0019481 [L-alanine catabolic process, by transamination]
GO:0030170 [pyridoxal phosphate binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0046135 [pyrimidine nucleoside catabolic process]
GO:0046487 [glyoxylate metabolic process]
GO:0047305 [(R)-3-amino-2-methylpropionate-pyruvate transaminase activity]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 439 aa
49.3 kDa 		No 0
AGXT2-201
ENSP00000479154
ENST00000618015
Q9BYV1 [Direct mapping]
Alanine--glyoxylate aminotransferase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Show all
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0008453 [alanine-glyoxylate transaminase activity]
GO:0008483 [transaminase activity]
GO:0009436 [glyoxylate catabolic process]
GO:0019265 [glycine biosynthetic process, by transamination of glyoxylate]
GO:0019481 [L-alanine catabolic process, by transamination]
GO:0030170 [pyridoxal phosphate binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0046135 [pyrimidine nucleoside catabolic process]
GO:0046487 [glyoxylate metabolic process]
GO:0047305 [(R)-3-amino-2-methylpropionate-pyruvate transaminase activity]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 439 aa
49.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.