Expression of SLC12A7 in cancer - Summary - The Human Protein Atlas

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SLC12A7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC12A7
Gene description	Solute carrier family 12 (potassium/chloride transporter), member 7
Protein class	Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (REH)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA041652
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and urothelial cancer (favourable).
Liver cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041652

GENE INFORMATION
Gene name	SLC12A7 (HGNC Symbol)
Synonyms	DKFZP434F076, KCC4
Description	Solute carrier family 12 (potassium/chloride transporter), member 7 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	p15.33
Chromosome location (bp)	1050376 - 1112035
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113504 (version 83.38)
Entrez gene	10723
UniProt	Q9Y666 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y666
Antibodypedia	SLC12A7 antibodies

PROTEIN BROWSER

SLC12A7-001	SLC12A7-007	SLC12A7-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC12A7-001 ENSP00000264930 ENST00000264930	Q9Y666 [Direct mapping] Solute carrier family 12 member 7 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006884 [cell volume homeostasis] GO:0007268 [synaptic transmission] GO:0010107 [potassium ion import] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1083 aa 119.1 kDa	No	>9
SLC12A7-007 ENSP00000428854 ENST00000513223	H0YB78 [Direct mapping] Solute carrier family 12 member 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006884 [cell volume homeostasis] GO:0015379 [potassium:chloride symporter activity] GO:1902476 [chloride transmembrane transport] Show all	355 aa 40.5 kDa	No	2
SLC12A7-010 ENSP00000489285 ENST00000634447		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0006811 [ion transport] GO:0015377 [cation:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	989 aa 108.9 kDa	No	>9

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.